Human Leukocyte Antigen G 14 Base Pair Insertion/Deletion Polymorphism and COVID-19 Susceptibility and Severity in Egyptian Patients: A Case Control Study
Ali, D., El Shahaway, A., Ismail, N. (2023). Human Leukocyte Antigen G 14 Base Pair Insertion/Deletion Polymorphism and COVID-19 Susceptibility and Severity in Egyptian Patients: A Case Control Study. EKB Journal Management System, 32(1), 151-156. doi: 10.21608/ejmm.2023.277795
Dina M. Ali; Alia A. El Shahaway; Nagwan A. Ismail. "Human Leukocyte Antigen G 14 Base Pair Insertion/Deletion Polymorphism and COVID-19 Susceptibility and Severity in Egyptian Patients: A Case Control Study". EKB Journal Management System, 32, 1, 2023, 151-156. doi: 10.21608/ejmm.2023.277795
Ali, D., El Shahaway, A., Ismail, N. (2023). 'Human Leukocyte Antigen G 14 Base Pair Insertion/Deletion Polymorphism and COVID-19 Susceptibility and Severity in Egyptian Patients: A Case Control Study', EKB Journal Management System, 32(1), pp. 151-156. doi: 10.21608/ejmm.2023.277795
Ali, D., El Shahaway, A., Ismail, N. Human Leukocyte Antigen G 14 Base Pair Insertion/Deletion Polymorphism and COVID-19 Susceptibility and Severity in Egyptian Patients: A Case Control Study. EKB Journal Management System, 2023; 32(1): 151-156. doi: 10.21608/ejmm.2023.277795

Human Leukocyte Antigen G 14 Base Pair Insertion/Deletion Polymorphism and COVID-19 Susceptibility and Severity in Egyptian Patients: A Case Control Study

Egyptian Journal of Medical Microbiology
Volume 32, Issue 1, January 2023, Page 151-156  XML PDF (266.81 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2023.277795
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Authors
Dina M. Ali email orcid 1; Alia A. El Shahaway2; Nagwan A. Ismail3
1Tropical Medicine Department, Faculty of Human Medicine, Zagazig University
2Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Egypt
3Chest Department, Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: HLA-G inhibits the immune system and has been linked to the risk and prognosis of numerous infectious diseases. Objective: to investigate the impact of HLA-G 14 bp insertion/deletion polymorphism on the susceptibility and severity of COVID-19. Methodology: This was a case-control study that comprised a total of 86 participants divided into two equal groups: 43 healthy controls and 43 COVID-19 Egyptian patients. Determination of the genetic polymorphism was performed for all study participants. Results: We found a statistically significant difference between both cases and healthy controls as regards the distribution of HLA-G genotypes (p-value=0.018). Healthy controls were 5.2 times more likely to have the INS/DEL genotype (OR= 5.2; 95% CI: 1.57-17.18) (p-value=0.007) and 2.7 times to have the INS/INS genotype (OR= 2.76; 95% CI: 0.76-9.96 (p-value=0.11). Although we found an association between HLA-G polymorphism and COVID-19 severity (p-value=0.002), however, it was not confirmed by logistic regression. The presence of the INS/INS genotype was linked to higher odds of developing severe COVID-19 (OR=3.66; 95% CI: 0.173-77.5) and (OR= 6.28; 95% CI: 0.577- 68.4) in comparison to the DEL/DEL and INS/DEL genotypes, respectively, but these higher odds were not statistically significant (p-value=0.40 and 0.13), respectively. Conclusion: Among healthy controls, the most common genotype was INS/DEL. The DEL/DEL genotype was associated with increased susceptibility to COVID-19 infection. HLA-G polymorphisms do not affect the severity of COVID-19.
Keywords
HLA-G; HLA; COVID-19; SARS-CoV-2; Gene Polymorphism; Genotyping; Human Leukocyte Antigen; Egypt
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