Cytotoxic activity of some benzo[4,5]imidazo[1,2-a]pyrimidine derivatives against the human cancer cell lines HepG2 and MCF-7 | ||||
Egyptian Journal of Chemistry | ||||
Volume 66, Issue 9, September 2023, Page 237-243 PDF (834.75 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2023.173878.7209 | ||||
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Authors | ||||
Wahid Basyouni1; Samir Youssef Abbas2; Khairy A.M El-bayouki3; Mohamed Y. El-kady4; Nagwa M. Abdelazeem 5; Reham Dawood6; Mohamed A. Shemis7 | ||||
1National Research Centre | ||||
2Organometalic and Organometalliod Chemistry Department, National Research Centre | ||||
3Organometallic chemistry Department, National research centre | ||||
4Ain Shams university | ||||
5Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt. | ||||
6Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt | ||||
7Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute,Cairo, Egypt. | ||||
Abstract | ||||
Different benzo[4,5]imidazo[1,2-a]pyrimidine derivatives were synthesized in high purity and yields with short reaction times by the reaction of 2-aminobenzimidazole, aldehydes and active carbonyl compounds in the presence of Silica sulfuric acid/ethylene glycol (SSA/EG) as a catalyst. Cytotoxicity of the synthesized benzo[4,5]imidazo[1,2-a]pyrimidine derivatives 1-6 was carried out against the two human cancer cell lines, hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) as well as Vero cells (normal cells). | ||||
Keywords | ||||
Benzo[4,5]imidazo[1,2-a]pyrimidine; Cytotoxicity; human cancer cell lines; Hepatocellular carcinoma; breast carcinoma | ||||
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