ANTI-SCHISTOSOMAL AND ANTIFIBROTIC EFFECTS OF RESVERATROL LOADED ON NIOSOMES IN MURINE SCHISTOSOMIASIS MANSONI | ||||
Journal of the Egyptian Society of Parasitology | ||||
Volume 52, Issue 3, December 2022, Page 471-482 PDF (1.51 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jesp.2022.278368 | ||||
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Authors | ||||
WALAA H. EID1; IBRAHIM A. ABOUL ASAAD1; DAREEN A. MOHAMED ALI2; YUSUF A. HAGGAG3; AMINA M. SALAMA1 | ||||
1Department of Medical Parasitology | ||||
2Department of Pathology | ||||
3Department of Pharmaceutical Technology | ||||
Abstract | ||||
Schistosomiasis is one of the most prevalent parasites causing morbidity. Praziquantel (PZQ) is recommended drug for all Schistosoma spp. But, it exhibits low and erratic bioavailability and drug resistance. This study evaluated the anti-parasitic and anti-fibrotic effects of resveratrol (RSV) loaded on niosomes in murine schistosomiasis mansoni. Mice were divided into 3 groups: GI (control) subdivided into (Ia) uninfected untreated, (Ib) infected untreated, and (Ic) infected treated with niosomes nanoparticles (NPs). GII: received niosomes-PZQ and subdivided into (IIa) received a dose of 250mg/kg body weight /24hrs in 2 doses of 3hrs apart at 4th wk. P.I. (antiparasitic) and (IIb) received a dose of 500mg/kg body weight divided equally on 2 consecutive days at 10th wk. P.I. (antifibrotic). GIII: subdivided into 2 subgroups (IIIa & IIIb) received niosomes- RSV in a dose of 20mg/kg bodyweight /24hrs 3 times a week for 2 wks. at 4th & 10th wks. P.I. respectively. All mice were subjected to parasitological, histopathological, & immunohistochemical (α-SMA) studies, as well as, ALT & AST serum levels evaluation. Niosomes-RSV caused significant reduction in adults’ count, hepatic eggs, ALT & AST levels and hepatic granulomas’ size and number. Niosomes NPs alone caused significant reduction only in adults’ count and hepatic eggs compared to infected untreated ones. | ||||
Keywords | ||||
Schistosomiasis mansoni; Hepatic fibrosis; Resveratrol; Niosomes; α-SMA | ||||
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