Liver abnormalities and clinical outcome of covid -19 infected patients | ||||
| Minia Journal of Medical Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 10 January 2023 | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/mjmr.2023.180141.1234 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
gehad abdelrahamn mohamed  1; yousef ismail moussa2; fatma mokhtar shaban3
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| 1قسم الباطنه العامه جامعه المنيا | ||||
| 2headof internal medicine department minia university | ||||
| 3internal medicine minia university | ||||
| Abstract | ||||
| Liver harm is discovered in up to half hospitalized COVID19 patients and result either from actions of SARS-CoV2 or from medicine treatment. the current paper introduces Associate describes the pathways by SARS-CoV-2 resulting in liver injury. this will be caused by direct binding of the virus and native actions in cholangiocytes, however might also indirectly result from the final state of drive and general inflammation in COVID-19 patients. Aim of the study: The aim of the current study to evaluate liver abnormalities and the effect of these changes in prognosis of patients infected with Covid-19 in Minia University hospital. Materials& Methods: This study is a a prospective study, during the period from May to December, 2021.This study included 325 patients with covid-19 Minia university hospitals. Results: Significantly increased levels of TB and DB (p<0.0001*) were seen in patients with abnormal liver enzyme levels and liver injury as compared to patients with normal levels and normal liver . Significant increase in the levels of AlT and AST was(p<0.0001*) CRP and ferritin p<0.0001) peaks were observed on 2nd and 3rd day of admission respectively. positive correlation was found between the levels of these inflammatory markers and liver function parameters in covid 19 patient . Conclusion: More than half of patients admitted to the hospital with SARS-CoV-2 infection had an abnormal liver function which was found to be associated with raised levels of inflammatory markers. Significantly higher proportions of patients with liver disease and were at higher risk of progressing to severe disease. | ||||
| Keywords | ||||
| Covid -19; Drug hepatotoxicity; Inflammatory response; Liver function; Liver pathology | ||||
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