Alarming Antibiotic Resistance Pattern of Bacterial Isolates in Neonatal Sepsis: A Study from Egypt
Raafat Hamed, R., Dwedar, R., Bassyouni, R., Emira, A., Abd El-Hmid, R., Dowidar, M., Hegab, A. (2023). Alarming Antibiotic Resistance Pattern of Bacterial Isolates in Neonatal Sepsis: A Study from Egypt. EKB Journal Management System, 32(2), 31-39. doi: 10.21608/ejmm.2023.279742
Reham M. Raafat Hamed; Reham Dwedar; Rasha Bassyouni; Ahmed S. Emira; Rehab G. Abd El-Hmid; Mona A. Dowidar; Asmaa Hegab. "Alarming Antibiotic Resistance Pattern of Bacterial Isolates in Neonatal Sepsis: A Study from Egypt". EKB Journal Management System, 32, 2, 2023, 31-39. doi: 10.21608/ejmm.2023.279742
Raafat Hamed, R., Dwedar, R., Bassyouni, R., Emira, A., Abd El-Hmid, R., Dowidar, M., Hegab, A. (2023). 'Alarming Antibiotic Resistance Pattern of Bacterial Isolates in Neonatal Sepsis: A Study from Egypt', EKB Journal Management System, 32(2), pp. 31-39. doi: 10.21608/ejmm.2023.279742
Raafat Hamed, R., Dwedar, R., Bassyouni, R., Emira, A., Abd El-Hmid, R., Dowidar, M., Hegab, A. Alarming Antibiotic Resistance Pattern of Bacterial Isolates in Neonatal Sepsis: A Study from Egypt. EKB Journal Management System, 2023; 32(2): 31-39. doi: 10.21608/ejmm.2023.279742

Alarming Antibiotic Resistance Pattern of Bacterial Isolates in Neonatal Sepsis: A Study from Egypt

Egyptian Journal of Medical Microbiology
Volume 32, Issue 2, April 2023, Page 31-39  XML PDF (361.22 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2023.279742
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Authors
Reham M. Raafat Hamed email orcid 1; Reham Dwedar1; Rasha Bassyouniorcid 2; Ahmed S. Emira3; Rehab G. Abd El-Hmid4; Mona A. Dowidar5; Asmaa Hegaborcid 1
1Medical Microbiology and Immunology Department, Faculty of Medicine, Cairo University, Egypt
2Medical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Egypt
3MD Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Egypt; Microbiology Department, Alfa Laboratories, Cairo, Egypt
4Pediatric Department, Faculty of Medicine, Fayoum University, Egypt
5Medical Pharmacology, Faculty of Medicine, Cairo University, Egypt
Abstract
Background: Sepsis in the neonatal intensive care unit (NICU) remains one of the most significant causes of morbidity and mortality, especially for preterm. Multi-drug-resistant-organisms (MDROs) are emerging as important pathogens that cause neonatal sepsis in NICU.  Objective: to review the epidemiology of the microorganisms implicated in neonatal sepsis while shedding the light on the percentage of Multiple-drug-resistant (MDR) and Extensive-Drug-Resistance (XDR) microorganisms in addition to investigating their antibiotic susceptibility pattern. Methodology: This is a cross-sectional prospective study of a 24-month duration including data from culture-proven neonatal sepsis patients admitted at NICU, from Fayoum University Pediatric Hospital. Results: Klebsiella species was the most isolated organism from blood (46%), and 87.6% of isolates were MDR organisms (332/379). The resistance pattern was as follows: 66.5% of resistance owed to Gram-negative bacilli; of them 52% were XDR, 13.2% were MDR, 0.8% were Pan drug Resistant and 0.5% were Difficult-to-Treat (DTR)-Pseudomonas species. Gram-positive cocci were responsible for 21.1 % of MDR; 20.8% MRSA and 0.3% VRE. Total MDR accounted for 34.3% of isolates. The isolates showed significant resistance to most tested antibiotics (p<0.05) (doxycycline, tetracycline, amikacin, cefoxitin, meropenem, imipenem, ertapenem, piperacillin-tazobactam, and ampicillin-sulbactam. Significant sensitivity was detected to linezolid, vancomycin, and tigecycline. Conclusion: There is an alarming increase in the resistance rates among cases of neonatal sepsis. The application of an antibiotic stewardship program is essentially needed to stop the dramatic increase in antibiotic resistance and fight the development of MDROs.
Keywords
Neonatal Sepsis; Multi-drug-resistant-organisms; neonatal intensive care unit; Klebsiella species
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