Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats
Helal, E., Al-Shamrani, A., Abdelaziz, M., El-Gamal, M. (2019). Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats. EKB Journal Management System, 74(7), 1552-1558. doi: 10.21608/ejhm.2019.28025
Eman G.E. Helal; Abdullah Al-Shamrani; Mohamed A. Abdelaziz; Mariam S. El-Gamal. "Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats". EKB Journal Management System, 74, 7, 2019, 1552-1558. doi: 10.21608/ejhm.2019.28025
Helal, E., Al-Shamrani, A., Abdelaziz, M., El-Gamal, M. (2019). 'Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats', EKB Journal Management System, 74(7), pp. 1552-1558. doi: 10.21608/ejhm.2019.28025
Helal, E., Al-Shamrani, A., Abdelaziz, M., El-Gamal, M. Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats. EKB Journal Management System, 2019; 74(7): 1552-1558. doi: 10.21608/ejhm.2019.28025

Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats

The Egyptian Journal of Hospital Medicine
Article 12, Volume 74, Issue 7, January 2019, Page 1552-1558  XML PDF (675.33 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.28025
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Authors
Eman G.E. Helalorcid 1; Abdullah Al-Shamrani2; Mohamed A. Abdelaziz3; Mariam S. El-Gamal1
1Department of Zoology, Faculty of Science (Girls), Al-Azhar University
22Pediatric Pulmonology and Sleep Medicine, Prince Sultan Medical Military City, King Saud bin Abdulaziz University and Health Science
3Medical Physiology, Faculty of Medicine, Al-Azhar University
Abstract
Background: Non-nutritive sweeteners (NNSs) are becoming popular as sugar substitutes for diabetic patients or to decrease body weight. Aim of the work: This study was aimed to determine the effects of sucralose and sodium saccharin on some physiological parameters in male albino rats. Materials and methods: We used thirty male albino rats weighing from 100 to120 gm. The period of the experiment was 30 days. The animals were divided into three groups; Group 1: control, Group 2: rats received sucralose and group 3: rats received sodium saccharin. The following parameters were processed: serum glucose, ASAT, ALAT, serum creatinine, serum urea, protein and lipid profiles and hormonal levels (insulin, testosterone, serum T3 and T4). Results: There was an increase in ASAT and ALAT activities, serum creatinine and serum urea levels in group 2 and group 3, lipid profile in the group received sucralose (TC and HDL) and T3&T4 in the group received saccharin as compared to the control group. Meanwhile, a drop in serum glucose, insulin, total protein, albumin, albumin/globulin ratio and triglycerides in group 2 and group 3, lipid profile in the group received saccharin (TC and HDL) and T3&T4 in the group received sucralose was observed when compared to the control group. Conclusion: it could be concluded that sucralose and sodium saccharin must be carefully used because they have very dangerous effects-especially sodium saccharin- and we have to replace them with natural sugar.
Keywords
sucralose; sodium saccharin; ASAT; ALAT; T3; T4; testosterone; Insulin
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