Association of Monocyte to High-Density Lipoprotein Ratio with Contrast-Induced Nephropathy in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention
Emara, A., Elhelbawy, A., Samy, N. (2023). Association of Monocyte to High-Density Lipoprotein Ratio with Contrast-Induced Nephropathy in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention. EKB Journal Management System, 90(1), 1069-1074. doi: 10.21608/ejhm.2023.280259
Ahmed A. Emara; Ahmed Abdelsamie Elhelbawy; Neveen I. Samy. "Association of Monocyte to High-Density Lipoprotein Ratio with Contrast-Induced Nephropathy in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention". EKB Journal Management System, 90, 1, 2023, 1069-1074. doi: 10.21608/ejhm.2023.280259
Emara, A., Elhelbawy, A., Samy, N. (2023). 'Association of Monocyte to High-Density Lipoprotein Ratio with Contrast-Induced Nephropathy in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention', EKB Journal Management System, 90(1), pp. 1069-1074. doi: 10.21608/ejhm.2023.280259
Emara, A., Elhelbawy, A., Samy, N. Association of Monocyte to High-Density Lipoprotein Ratio with Contrast-Induced Nephropathy in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention. EKB Journal Management System, 2023; 90(1): 1069-1074. doi: 10.21608/ejhm.2023.280259

Association of Monocyte to High-Density Lipoprotein Ratio with Contrast-Induced Nephropathy in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention

The Egyptian Journal of Hospital Medicine
Article 159, Volume 90, Issue 1, January 2023, Page 1069-1074  XML PDF (493.2 K)
DOI: 10.21608/ejhm.2023.280259
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Authors
Ahmed A. Emara; Ahmed Abdelsamie Elhelbawy email ; Neveen I. Samy
Cardiology department,faculty of medicine, menoufia university, shebin elkom, Egypt
Abstract
Background: Following primary percutaneous coronary intervention (PCI), contrast-induced nephropathy (CIN) is linked to higher mortality and morbidity. The monocyte to high density lipoprotein cholesterol ratio (MHR), which has been used as a novel predictive marker in patients with cardiovascular and renal disorders, has been linked in several studies to a number of negative cardiovascular outcomes.
Objective: The current study was conducted to explore correlation between monocyte to HDL ratio and CIN after primary PCI in patients presented with ST-segment Elevation Myocardial Infarction (STEMI).
Patients and methods: A total of 80 patients with acute STEMI were included. Patients were differentiated into two groups according to development of contrast induced nephropathy; Group (A) Patients who developed contrast induced nephropathy, and Group (B) Patients did not develop contrast induced nephropathy. CIN was defined as either a 25% increase in serum creatinine from baseline or 0.5 mg/dL increase in absolute value, within 48-72 h of intravenous administration of contrast medium.
Results: A total of 16 (20%) patients developed CIN. MHR was significantly higher in CIN positive group [mean 0.0202 (range 0.009-0.0633) 108/mg] than non-CIN group [mean 0.0129 (range 0.0031-0.0307) 108/mg] with P-value = 0.003. MHR was also significantly correlated with creatinine levels 48 hours after PCI (rs: 0.322, P: 0.004). ROC statistical analysis showed that MHR >0.0131 was the best cutoff values for predicting contrast induced nephropathy with sensitivity 76% and specificity 71.2%.
Conclusion: Higher MHR levels may predict CIN development after primary PCI in STEMIpatients.
 

 
 
 
Keywords
Percutaneous coronary intervention; Contrast-induced nephropathy; High density lipoprotein cholesterol ratio; Myocardial Infarction
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