Predictors Of Mortality In Outborns With Neonatal Sepsis:Aprospective Observational Study

Abdel Haie, Omima mohamed; El.Sabbagh, Ghada Gamal; Elsayed, Adel shebl; AbdElatty, Rania I.

doi:10.21608/bmfj.2023.170637.1693

	Predictors Of Mortality In Outborns With Neonatal Sepsis:Aprospective Observational Study
Benha Medical Journal
Article 3, Volume 41, Special issue (Pediatrics), January and February 2024, Page 19-29 PDF (525.58 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.170637.1693
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Authors
Omima mohamed Abdel Haie¹; Ghada Gamal El.Sabbagh ²; Adel shebl Elsayed³; Rania I. AbdElatty⁴
¹Assistant Professor of Pediatric Faculty of Medicine – Benha University
²Department of Pediatric Faculty of Medicine &ndash; Benha University
³Professor of Pediatric Faculty of Medicine – Benha University
⁴Department of Paediatrics- Faculty of Medicine-Benha University
Abstract
Background:Mortality in outborns with Neonatal sepsis result from interaction of maternal-feotal colonization,transplacental immunity and physical and cellular defence mechanisms of neonates.Objective:The objective of this study was to determine risk factors 0f mortality in outborn with neonatal sepsis.Materials and Methods:A 6-months prospective observational study was done at neonatal intensive care unit of benha university hospital and serselyan general hospital.All outborn neonates with maternal and neonatal risk factors of sepsis were enrolled. Blood culture ,sepsis screen and other needed investigations were performed.Results:The mortality rate among outborn with neonatal sepsis was42%.The common presentations among outborns with neonatal sepsis were Hypothermia,convulsions,cyanosis and poor suckling.The,significant risk factors of mortality include Malesex(p=0.021),gestationalage(p=0.027), presence of convulsions(p=0.003), cyanosis(p=0.02), hypothermia(p=0.009), mottling(p=0.001),poor suckling(p=0.001),positive c- reactive protein(p=0.009), Anemia(p=0.011)..Maternal factors such as Premature rupture of membranes(p=0.047) and hypertension during pregnancy(p=0.001)and diabetes mellitus(p=0.017) were statistically significant associated with mortality in outborn neonatal sepsis.On multivariate logistic regression Temprature on admission and distance during transport to hospital were the predictive factors of mortality in outborn neonatal sepsis.Conclusion:Long distance tranelled with neonates during transport to hospital and presentation with hypothermia at admistion , were the independent risk factors of mortality in outborn neonatal sepsis.
Keywords
Neonatal sepsis; outborn neonates; mortality predictors


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