The use of injectable plasma rich fibrin (I-PRF) versus simvastatin gel in surgical management of infra-bony defects (A Randomized Controlled Clinical Trial)
Saleh, N., Ibrahim, S., Ezzatt, O. (2023). The use of injectable plasma rich fibrin (I-PRF) versus simvastatin gel in surgical management of infra-bony defects (A Randomized Controlled Clinical Trial). EKB Journal Management System, 69(1), 353-362. doi: 10.21608/edj.2022.168262.2312
Nada Saleh; Suzan Ibrahim; Ola Ezzatt. "The use of injectable plasma rich fibrin (I-PRF) versus simvastatin gel in surgical management of infra-bony defects (A Randomized Controlled Clinical Trial)". EKB Journal Management System, 69, 1, 2023, 353-362. doi: 10.21608/edj.2022.168262.2312
Saleh, N., Ibrahim, S., Ezzatt, O. (2023). 'The use of injectable plasma rich fibrin (I-PRF) versus simvastatin gel in surgical management of infra-bony defects (A Randomized Controlled Clinical Trial)', EKB Journal Management System, 69(1), pp. 353-362. doi: 10.21608/edj.2022.168262.2312
Saleh, N., Ibrahim, S., Ezzatt, O. The use of injectable plasma rich fibrin (I-PRF) versus simvastatin gel in surgical management of infra-bony defects (A Randomized Controlled Clinical Trial). EKB Journal Management System, 2023; 69(1): 353-362. doi: 10.21608/edj.2022.168262.2312

The use of injectable plasma rich fibrin (I-PRF) versus simvastatin gel in surgical management of infra-bony defects (A Randomized Controlled Clinical Trial)

Egyptian Dental Journal
Article 17, Volume 69, Issue 1 - Serial Number 3, January 2023, Page 353-362  XML PDF (851.79 K)
Document Type: Original Article
DOI: 10.21608/edj.2022.168262.2312
View on SCiNiTO View on SCiNiTO
Authors
Nada Saleh email orcid 1; Suzan Ibrahimorcid 2; Ola Ezzattorcid 3
1Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Ain Shams University.
2Associate Professor, Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Ain Shams University
3Professor, Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dentistry, Ain Shams University
Abstract
Objectives: Numerous studies have described the benefits of the injectable plasma rich fibrin (I-PRF) and simvastatin (SMV) gel separately in periodontal regeneration. However, there has been a lack of clinical trials comparing the use of these two agents. The aim of this study was to compare the clinical efficacy of open flap debridement (OFD) either with (I-PRF) or 1.2 % (SMV) gel in the management of patients having infra-bony defects (IBDs).
Subjects and methods: Twenty patients, having stage III grade B periodontitis with (IBDs) were recruited and randomly allocated to either; Group I (I-PRF) (n=10) undergoing (OFD) followed by single application of I-PRF, or Group II (SMV) (n=10) undergoing (OFD) followed by application of 1.2% simvastatin gel. The following clinical parameters were measured at baseline, and 6 months post-operative; clinical attachment level (CAL), periodontal pocket depth (PD), plaque index (PI) and gingival index (GI), as clinical parameters as well as, defect depth as a radiographic parameter.
Results: Both groups showed significant reduction regarding all clinical parameters with no statistically significant difference between groups at 6 months post-operative. SMV demonstrated a statistically significant higher reduction in defect depth compared to I-PRF.
Conclusion: I-PRF and SMV 1.2% gel as adjunctive local delivery regenerative therapy to (OPD) were effective and comparable clinically. Infrabony defects treated with SMV 1.2 % gel showed better bone fill compared to I-PRF radiographically.
Keywords
Infrabony defects; I-PRF; Periodontitis; Simvastatin; Stage III grade B
Statistics
Article View: 210
PDF Download: 178