The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients. | ||||
| Microbes and Infectious Diseases | ||||
| Article 7, Volume 4, Issue 2, May 2023, Page 393-400 PDF (581.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2023.184087.1439 | ||||
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| Authors | ||||
Mira Atef1; Hala Ramadan   2; Hanan Abdel-Haleem1; Rasha Ahmed Abdalaziz3; Aya Mohamed Al-sharif1; Reem Ibrahim Mohamed El-Korashy4; Youssef Mohamed Amin Soliman4; Sabah Ahmed Hussein4; Ahmed Mohamed Hashem5; Manal Mohamed Kamal6; Mona Mohsen Abdulsalam Abdullatif7; Mohammed Mostafa Abdel Razik8; Ahmed Ramadan1
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| 1Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt. | ||||
| 2Internal Medicine department, Faculty of Medicine, Cairo University, Egypt. | ||||
| 3Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University. | ||||
| 4Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt. | ||||
| 5National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt. | ||||
| 6Clinical and Chemical Pathology department, Faculty of Medicine, Cairo University,Egypt. | ||||
| 7Clinical and Chemical Pathology department, Faculty of Medicine, Cairo University, Egypt. | ||||
| 8Public health and Community Medicine department, faculty of medicine, Cairo University, Egypt. | ||||
| Abstract | ||||
| Background and rationale: Coronavirus disease 2019 (COVID-19) infection is a respiratory tract infection because of a novel coronavirus. The clinical picture ranges from asymptomatic to severe manifestations mandating intensive care and respiratory support. We aimed to assess the serum level of iron, total iron binding capacity (TIBC), and transferrin saturation in COVID-19 patients and their relation to disease severity and outcome. Methodology: This observational cross-sectional analytical study was conducted on 100 confirmed cases of COVID-19 who were admitted to Kasr Al-Ainy hospitals between June and December 2020.Serum levels of iron, total iron binding capacity (TIBC), and transferrin saturation were measured for all study populations. Result: One hundred patients were involved in this research, 51males and 49 females, with a mean age of 51±14.9years. Regarding the disease severity,53% were moderate cases, 34% were mild, and 13% were severe cases. Fifty-two (54.2%) patients showed normal serum levels of iron, 38 patients (39.6%) showed high serum levels of iron, and 6 patients (6.3%) showed low serum levels of iron. The mean ±SD values of iron, TIBC, and transferrin saturation were 163.1±105 mcg/dL, 366 ± 162.6 mcg/dL, 44.4 ± 20.2 %, respectively. Iron, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association as regards either COVID-19 severity or mortality. Mortality and deterioration were detected in 31.7% out of 60 patients with COVID-19. The results showed that obese patients showed a higher percentage of severe COVID-19,which was statistically significant (p < /em>=0.037).There was a statistically significant higher mortality rate in patients with severe COVID-19 (p < /em>=0.000).High mortality was observed significantly in patients with diabetes mellitus (p < /em>=0.041).Iron levels, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association regarding either COVID-19 severity or mortality. Conclusion: In our study, COVID-19 severity was not related to iron metabolism but was affected by obesity and diabetes mellitus. COVID-19 mortality was significantly associated with diabetes. | ||||
| Keywords | ||||
| Iron; TIBC; COVID-19 patients; Disease severity | ||||
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