Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation versus Minoxidil® 5% in The Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study
Abdel-Moiti, A., Badria, F., Aly, S., Fayed, H. (2023). Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation versus Minoxidil® 5% in The Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study. EKB Journal Management System, 90(1), 1284-1293. doi: 10.21608/ejhm.2023.282023
Amany Moustafa Abdel-Moiti; Farid Abd-Elreheim Badria; Sara Hamdy Fouad Aly; Hassan Abdel-Raheim Fayed. "Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation versus Minoxidil® 5% in The Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study". EKB Journal Management System, 90, 1, 2023, 1284-1293. doi: 10.21608/ejhm.2023.282023
Abdel-Moiti, A., Badria, F., Aly, S., Fayed, H. (2023). 'Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation versus Minoxidil® 5% in The Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study', EKB Journal Management System, 90(1), pp. 1284-1293. doi: 10.21608/ejhm.2023.282023
Abdel-Moiti, A., Badria, F., Aly, S., Fayed, H. Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation versus Minoxidil® 5% in The Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study. EKB Journal Management System, 2023; 90(1): 1284-1293. doi: 10.21608/ejhm.2023.282023

Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation versus Minoxidil® 5% in The Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study

The Egyptian Journal of Hospital Medicine
Article 192, Volume 90, Issue 1, January 2023, Page 1284-1293  XML PDF (612.45 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.282023
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Authors
Amany Moustafa Abdel-Moiti email ; Farid Abd-Elreheim Badria; Sara Hamdy Fouad Aly; Hassan Abdel-Raheim Fayed
Abstract
Background: Valproic acid (VPA), is often used as an anticonvulsant drug that activates the Wnt/β-catenin signaling pathway and blocks GSK3b, a glycogen synthase kinase, and though connected with increasing hair growth and induction of anagen. Currently, only FDA-approved two percent topical minoxidil is available therapy to treat female pattern baldness. Objective: This randomized controlled clinical trial study aimed to evaluate the effectiveness of topical VPA and 5% topical minoxidil for treating Female pattern hair loss (FPHL).
Patients and methods: This study included 81 patients with FPHL who were allocated into three groups randomly (27 treated with topical sodium valproate-loaded nano spanlastics formulation, 27 treated with minoxidil® 5% lotion, and 27 treated with saline bottled containers using transdermal delivery using a derma roller for 6 months. The included patients were chosen randomly from the Outpatient Clinic of Dermatology, Andrology & STDs Department, Mansoura University Hospitals. All patients were subjected to history taking, and general dermatological and scalp examination.
Results: In comparison to the control group, the mean change in the total number of hairs was substantially larger in the VPA and minoxidil groups (P = 0.047). Although the majority of adverse events in both groups were moderate and self-limiting, the variations in prevalence rates across the groups were comparable (P = 0.72).
Conclusion: Topical VPA and 5% minoxidil increased the total hair count of our patients ; therefore, topical VPA is a potential therapy option for FPHL.
 
Keywords
Female Pattern Hair Loss; β-catenin; Glycogen synthase kinase 3; Hair; Valproic acid; Wnt; Minoxidil
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