Serum 25-hydroxyvitamin D Concentration and Breast Cancer Risk in Egyptian Women in South Egypt | ||||
| SECI Oncology Journal | ||||
| Volume 11, Issue 1, January 2023, Page 1-11 | ||||
 View on SCiNiTO | ||||
| Abstract | ||||
| Purpose: to examine the relationship between circulating vitamin D level and risk of breast cancer. Methods: This case-control study was conducted in the surgical oncology departments at Assiut University's South Egypt Cancer Institute from September 1 st, 2019 to May 31st, 2020. The study enrolled 140 people (70 cases with newly diagnosed breast cancer and 70 age-matched controls from hospital visitors). The researcher obtained informed consent from the study participants. The questionnaire included inquiries about the following aspects: serum vitamin D level; data pertinent to demographic and clinical characteristics; parity; menstrual and contraceptive histories; dietary history; sun exposure; BMI; and waist-to-hip ratio were collected by face-to-face interview and compared between the two groups. Regarding the breast cancer cases, pathologic characteristics were evaluated against the vitamin D level. Results: The mean age of breast cancer cases was 51.54 vs. 50.11±5.44 years in the control group. Remarkable proportions of breast cancer cases and controls were found to have a low serum level of vitamin D. The study revealed that 94.3% of cases have vitamin D levels less than 20 ng/mL versus 78.6% in the control group. The odds ratio of breast cancer associated with a vitamin D level 20 ng/ml was more than 5 times higher with levels 20 ng/ml after adjustment for age, BMI, sun exposure, family income, education status, and family history of breast cancer. Conclusion: Because vitamin D levels were found to be associated with the risk of breast cancer in the current study, every effort should be made to improve women's health and socioeconomic status, particularly in less privileged communities such as rural upper Egypt. | ||||
| Keywords | ||||
| breast cancer; vitamin D deficiency; dietary history | ||||
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