Thiobarbituric Acid Reactive Substance Cord Blood as a Diagnostic Marker of Early-onset Neonatal Sepsis in Preterm Neonates
Ismail, R., Shaaban, H., Shaaban, M., Emam, A. (2019). Thiobarbituric Acid Reactive Substance Cord Blood as a Diagnostic Marker of Early-onset Neonatal Sepsis in Preterm Neonates. EKB Journal Management System, 28(1), 1-7. doi: 10.21608/ejmm.2019.282302
Rania I.H. Ismail; Hebatallah A. Shaaban; Menat Allah A. Shaaban; Ahmed M. Emam. "Thiobarbituric Acid Reactive Substance Cord Blood as a Diagnostic Marker of Early-onset Neonatal Sepsis in Preterm Neonates". EKB Journal Management System, 28, 1, 2019, 1-7. doi: 10.21608/ejmm.2019.282302
Ismail, R., Shaaban, H., Shaaban, M., Emam, A. (2019). 'Thiobarbituric Acid Reactive Substance Cord Blood as a Diagnostic Marker of Early-onset Neonatal Sepsis in Preterm Neonates', EKB Journal Management System, 28(1), pp. 1-7. doi: 10.21608/ejmm.2019.282302
Ismail, R., Shaaban, H., Shaaban, M., Emam, A. Thiobarbituric Acid Reactive Substance Cord Blood as a Diagnostic Marker of Early-onset Neonatal Sepsis in Preterm Neonates. EKB Journal Management System, 2019; 28(1): 1-7. doi: 10.21608/ejmm.2019.282302

Thiobarbituric Acid Reactive Substance Cord Blood as a Diagnostic Marker of Early-onset Neonatal Sepsis in Preterm Neonates

Egyptian Journal of Medical Microbiology
Article 1, Volume 28, Issue 1, January 2019, Page 1-7  XML PDF (469.71 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2019.282302
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Authors
Rania I.H. Ismail1; Hebatallah A. Shaaban email 2; Menat Allah A. Shaaban3; Ahmed M. Emam4
1Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Background: Neonatal sepsis (NS) promotes unbalanced production of oxidant and anti-oxidant substances, causing excess of free oxygen radicals which may lead to tissue damage. NS carries high risk of morbidity and mortality, thus identification of biomarker to optimize early diagnosis and therapeutic interventions is highly desirable. Objectives: to detect cord blood thiobarbituric acid reactive substance (TBARS) in preterm neonates with maternal risk factor for sepsis as predictors of early onset neonatal sepsis (EOS). Methodology: cord TBARS was measured in 80 preterm neonates with antenatal risk factors for EOS, and classified into two groups: sepsis (n=25) and no-sepsis (n=55). Results: TBARS was significantly higher in sepsis than no-sepsis groups 10.50 (6.5 – 20.5) vs 3.00 (2.2 - 3.8) nmol/ml, (p=0.000). TBARS was significantly higher in culture proven sepsis than negative culture patients. TBARS was significantly higher in died neonates than survivors. Conclusion: cord TBARS in preterm neonates with maternal risk factor for sepsis can be used as diagnostic and prognostic biomarker for EOS.
3Clinical pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4Armed forces Hospital, Alexandria, Egypt
Abstract
Background: Neonatal sepsis (NS) promotes unbalanced production of oxidant and anti-oxidant substances, causing excess of free oxygen radicals which may lead to tissue damage. NS carries high risk of morbidity and mortality, thus identification of biomarker to optimize early diagnosis and therapeutic interventions is highly desirable. Objectives: to detect cord blood thiobarbituric acid reactive substance (TBARS) in preterm neonates with maternal risk factor for sepsis as predictors of early onset neonatal sepsis (EOS). Methodology: cord TBARS was measured in 80 preterm neonates with antenatal risk factors for EOS, and classified into two groups: sepsis (n=25) and no-sepsis (n=55). Results: TBARS was significantly higher in sepsis than no-sepsis groups 10.50 (6.5 – 20.5) vs 3.00 (2.2 - 3.8) nmol/ml, (p=0.000). TBARS was significantly higher in culture proven sepsis than negative culture patients. TBARS was significantly higher in died neonates than survivors. Conclusion: cord TBARS in preterm neonates with maternal risk factor for sepsis can be used as diagnostic and prognostic biomarker for EOS.
Keywords
Oxidative stress; Preterm; Neonatal sepsis; TBARS
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