Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women
Yousif, Z., Salih, L. (2023). Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women. EKB Journal Management System, 90(1), 1467-1471. doi: 10.21608/ejhm.2023.282370
Zainab Omar Yousif; Lina A. Salih. "Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women". EKB Journal Management System, 90, 1, 2023, 1467-1471. doi: 10.21608/ejhm.2023.282370
Yousif, Z., Salih, L. (2023). 'Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women', EKB Journal Management System, 90(1), pp. 1467-1471. doi: 10.21608/ejhm.2023.282370
Yousif, Z., Salih, L. Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women. EKB Journal Management System, 2023; 90(1): 1467-1471. doi: 10.21608/ejhm.2023.282370

Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women

The Egyptian Journal of Hospital Medicine
Article 219, Volume 90, Issue 1, January 2023, Page 1467-1471  XML PDF (550.45 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.282370
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Authors
Zainab Omar Yousif email ; Lina A. Salih
Abstract
Background: The total number of oocytes, oocyte maturation, and oocyte fertilization all significantly affect how successful in vitro fertilization (IVF) is. Additionally, it has been demonstrated that several chemicals in follicular fluid, including cytokines and growth factors, have a major impact on follicular maturation, ovulation, and follicular atresia. One of these molecules, Pregnancy Associated Plasma Protein-A (PAPP-A), a part of the Insulin like Growth Factor (IGF) pathway, has been demonstrated to be generated by granulosa cells and present in follicular fluid. Objective: The aim of this study is to measure the level of Pregnancy Associated Plasma Protein-A (PAPP-A) in Follicular Fluid (FF) of infertile women undergoing ICSI, and to looking into the connections of PAPP-A with some reproductive hormones level.
Patients and methods: The study included infertile women from Al-Wazyria Hospital, Infertility and IVF Center, Baghdad (Iraq), from December 2021 to April 2022. This study was conducted on 45 infertile women who are set to start their ICSI cycle.
Results: FF PAPP-A was not significant with hormones level (FSH, LH, E2 and AMH) except PRO hormone was significant.
Conclusion: Outcomes show that no relation between studied reproductive hormones and FF PAPP-A level except PRO levels; it was the main cause from the egg to mature and release from the ovary.
 
Keywords
Associated Plasma Protein-A; Follicular Fluid; Insulin like Growth Factor; In-vitro fertilization; Case series; University of Baghdad
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