Toll-Like Receptor 7 Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infection, Correlation with HCV Outcome
Labeeb, A., Badr, E. (2019). Toll-Like Receptor 7 Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infection, Correlation with HCV Outcome. EKB Journal Management System, 28(1), 95-101. doi: 10.21608/ejmm.2019.282431
Azza Z. Labeeb; Eman A.E. Badr. "Toll-Like Receptor 7 Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infection, Correlation with HCV Outcome". EKB Journal Management System, 28, 1, 2019, 95-101. doi: 10.21608/ejmm.2019.282431
Labeeb, A., Badr, E. (2019). 'Toll-Like Receptor 7 Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infection, Correlation with HCV Outcome', EKB Journal Management System, 28(1), pp. 95-101. doi: 10.21608/ejmm.2019.282431
Labeeb, A., Badr, E. Toll-Like Receptor 7 Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infection, Correlation with HCV Outcome. EKB Journal Management System, 2019; 28(1): 95-101. doi: 10.21608/ejmm.2019.282431

Toll-Like Receptor 7 Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infection, Correlation with HCV Outcome

Egyptian Journal of Medical Microbiology
Article 13, Volume 28, Issue 1, January 2019, Page 95-101  XML PDF (380.26 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2019.282431
View on SCiNiTO View on SCiNiTO
Authors
Azza Z. Labeeb email 1; Eman A.E. Badr2
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Menoufia University, Egypt
2Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Egypt
Abstract
Background: The outcome of hepatitis C virus infection whether; natural viral clearance or progressive liver damage, is dependent on an efficient immune response. TLR7 is a pattern recognition receptor that can sense ssRNA viruses and is important contributor in the immune defense against HCV infection. Objectives: In this study, we attempted to evaluate if there is an association between HCV infection outcome and TLR7 single nucleotide polymorphism (SNP) rs179009. Methodology: 96 participants were included in this study, they were divided into 3 groups. Group (I); 39 patients had persistent HCV infection, group (II); 37 patients who cleared HCV infection, and group (III); 20 healthy controls. All participants were genotyped for TLR7 SNP rs179009 using Taq-Man SNP genoyping assay and real time PCR. Results: There was a notable difference between males and females regarding TLR7 SNP rs179009 genotypes distribution among HCV carriers and natural clearance groups. As, female patients carrying AA genotype were capable of clearing HCV virus efficiently compared with females carrying AG or GG genotype (OR = 1.02, 95% CI = 0.07-1.1, P = 0.042 ).Hence AA genotype appeared as a protective factor against persistence HCV infection among females. Whereas, AG genotype may be a risk factor for establishing persistence HCV infection in female patients(P<0.05). Concerning HCV infected males, no significant association was detected between TLR7 SNP rs179009 A or G genotype with HCV outcome. Conclusion: TLR7 SNP rs179009 may adjust the clearance or persistence of HCV outcome with different magnitudes between either males or females. These findings give us an idea about the role of TLR7 SNP, which, may be a predictor of HCV infection outcome and of the response to INF therapy. Hopefully, a future approach of TLR7-based therapy may be developed.
Keywords
Hepatitis C virus; Single Nucleotide Polymorphism; TLR7; genotyping
Statistics
Article View: 45
PDF Download: 23