Prevalence of Multidrug Resistant Organisms in Neonatal and Pediatric Intensive Care Units of Beni-Suef University Hospital
Ibrahim, H., Taha, G., Ibrahim, N., El Malah, W., Anwar, M. (2019). Prevalence of Multidrug Resistant Organisms in Neonatal and Pediatric Intensive Care Units of Beni-Suef University Hospital. EKB Journal Management System, 28(2), 27-35. doi: 10.21608/ejmm.2019.282666
Huda M. A. Ibrahim; Gamal Eldin M. M. Taha; Nermin Hassan Ibrahim; Waleed M. El Malah; Manal M. Anwar. "Prevalence of Multidrug Resistant Organisms in Neonatal and Pediatric Intensive Care Units of Beni-Suef University Hospital". EKB Journal Management System, 28, 2, 2019, 27-35. doi: 10.21608/ejmm.2019.282666
Ibrahim, H., Taha, G., Ibrahim, N., El Malah, W., Anwar, M. (2019). 'Prevalence of Multidrug Resistant Organisms in Neonatal and Pediatric Intensive Care Units of Beni-Suef University Hospital', EKB Journal Management System, 28(2), pp. 27-35. doi: 10.21608/ejmm.2019.282666
Ibrahim, H., Taha, G., Ibrahim, N., El Malah, W., Anwar, M. Prevalence of Multidrug Resistant Organisms in Neonatal and Pediatric Intensive Care Units of Beni-Suef University Hospital. EKB Journal Management System, 2019; 28(2): 27-35. doi: 10.21608/ejmm.2019.282666

Prevalence of Multidrug Resistant Organisms in Neonatal and Pediatric Intensive Care Units of Beni-Suef University Hospital

Egyptian Journal of Medical Microbiology
Volume 28, Issue 2, April 2019, Page 27-35  XML PDF (483.93 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2019.282666
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Authors
Huda M. A. Ibrahim1; Gamal Eldin M. M. Taha1; Nermin Hassan Ibrahim email 2; Waleed M. El Malah1; Manal M. Anwar3
1Pediatrics Department, Faculty of Medicine, Beni-Suef University, Egypt
2Medical Microbiology and Immunology Department, Faculty of Medicine, Beni-Suef University, Egypt
3Public Health and Community Medicine Department, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
Background: Hospital acquired infections are still a major cause of morbidity and mortality among neonates and children admitted to intensive care units Objectives: To determine the prevalence and clinical distribution of Multidrug resistant organisms (MDROs) in neonatal intensive care unit (NICU) and pediatric intensive care unit (PICU) of Beni-Suef University Hospital. Methodology: A cross-sectional study included 160 patients diagnosed with sepsis, 80 patients admitted at NICU and another 80 patients at PICU. Blood, sputum, urine were collected from each patient, to perform; CBC, CRP, culture and sensitivity. Identification of isolates was conducted by the various conventional methods. Thereafter, antimicrobial sensitivity tests were conducted for each isolate to detect MDROs. Results: Most of the isolates were MDROs (85.8%%) with high statistical significant difference regarding their frequencies. Most common Gram-negative isolate was klebsiella pneumoniae representing 36.7% of isolates. Candida albicans were significantly more frequent among PICU cases (p-value <0.05). MDR risk factors revealed that: length of stay (LOS) at the present ICU or LOS in another ICU before the current one were associated risk factors (p-value = 0.00001, 0.05 respectively). MDR Gram-negative isolates showed high resistance to ampicillin-sulbactam (98.8%) and were most sensitive to polymyxin (79.1%). In MDR Gram-positive yields, vancomycin (93%) and linozolide (100%) were the most effective, whilst, resistance was evident against ampicillin (93%). All Candida spp. isolates were most sensitive to amphotericin (93.1%) and most resistant to fluconazole (62%). The overall mortality rate was 32.5%: NICU deaths represented 52.5% and PICU deaths 12.5% with a significant difference between NICU and PICU. Conclusion: Prevalence rate of MDROs is extremely high among NICU and PICU patients even against newer categories of antibiotics, so, more strict infection control program should be applied.
Keywords
MDROs; antimicrobial resistance; NICU; PICU
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