Transforming Growth Factor Beta 2 (TGF-β2), Heat Shock Protein 70 (HSP70) And Interferon (IFN) γ As Biomarkers in Newly Diagnosed Autistic Children
Karm El din, M., El Shourbagy, O., Amin, M., Bayomy, I., Tony, A., Yosef, D. (2019). Transforming Growth Factor Beta 2 (TGF-β2), Heat Shock Protein 70 (HSP70) And Interferon (IFN) γ As Biomarkers in Newly Diagnosed Autistic Children. EKB Journal Management System, 28(2), 121-127. doi: 10.21608/ejmm.2019.282705
Magdy Karm El din; Omar E. El Shourbagy; Mohamed M. Amin; Ibrahim H. Bayomy; Abeer A. Tony; Doaa O.A. Yosef. "Transforming Growth Factor Beta 2 (TGF-β2), Heat Shock Protein 70 (HSP70) And Interferon (IFN) γ As Biomarkers in Newly Diagnosed Autistic Children". EKB Journal Management System, 28, 2, 2019, 121-127. doi: 10.21608/ejmm.2019.282705
Karm El din, M., El Shourbagy, O., Amin, M., Bayomy, I., Tony, A., Yosef, D. (2019). 'Transforming Growth Factor Beta 2 (TGF-β2), Heat Shock Protein 70 (HSP70) And Interferon (IFN) γ As Biomarkers in Newly Diagnosed Autistic Children', EKB Journal Management System, 28(2), pp. 121-127. doi: 10.21608/ejmm.2019.282705
Karm El din, M., El Shourbagy, O., Amin, M., Bayomy, I., Tony, A., Yosef, D. Transforming Growth Factor Beta 2 (TGF-β2), Heat Shock Protein 70 (HSP70) And Interferon (IFN) γ As Biomarkers in Newly Diagnosed Autistic Children. EKB Journal Management System, 2019; 28(2): 121-127. doi: 10.21608/ejmm.2019.282705

Transforming Growth Factor Beta 2 (TGF-β2), Heat Shock Protein 70 (HSP70) And Interferon (IFN) γ As Biomarkers in Newly Diagnosed Autistic Children

Egyptian Journal of Medical Microbiology
Volume 28, Issue 2, April 2019, Page 121-127  XML PDF (487.49 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2019.282705
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Authors
Magdy Karm El din1; Omar E. El Shourbagy1; Mohamed M. Amin email 2; Ibrahim H. Bayomy3; Abeer A. Tony4; Doaa O.A. Yosef5
1Department of Medical Studies for Children FPCS, Ain Shams University
2Department of Microbiology and Immunology, Faculty of Medicine, Aswan University
3Department of Microbiology and Immunology, Faculty of Medicine, Al-Azhar University
4Department of Neuropsychiatry, Faculty of Medicine, Aswan University
5M.Sc. of Pediatrics, Ministry of Health
Abstract
Background: Autism is a complex developmental condition that typically manifests in the first three years of life. Objectives: detection of plasma level of (TGF-β2), (HSP70) and (IFN) γ in children with Autism Spectrum Disorder (ASD) and to find out correlation between their plasma levels and severity of ASD. Methodology: 40 children newly diagnosed with ASD recruited from Child Outpatients Clinics, Faculty of Medicine, Ain Shams University. All children were subjected to developmental history, prenatal, Physical and neurological examination, Cognitive age using Stanford Bine intelligence scale to exclude other mental or neurobehavioral disorders and laboratory detection of plasma level of HSP70, TGF-β2 and INF-γ by an ELISA kit. Results: HSP70 was (15.901±2.638), IFNγ was (92.37±7.893) and TGFβ2 was (68.7±8.39), conclusion: There was a negative correlation between the level of TGFβ2 and CARS while there were a positive correlation between the level of HSP70 and IFN-γ with CARS.
Keywords
Autism Spectrum Disorder (ASD); TGFβ2; HSP70; IFNƳ; Childhood Autism Rating Scale (CARS)
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