THE PROTECTIVE ROLE OF COENZYME Q10 AGAINST NANDROLONE DECANOATE-INDUCED CARDIOTOXICITY IN RATS: BIOCHEMICAL, GENETIC, HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY. | ||||
| The Egyptian Journal of Forensic Sciences and Applied Toxicology | ||||
| Article 2, Volume 18, Issue 1, May 2018, Page 19-34 PDF (888.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejfsat.2018.28292 | ||||
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| Abstract | ||||
| Anabolic androgenic steroids (AAS) are still used broadly by athletes, even though they are barred in sports, to increase cardiac performance and muscle mass rapidly. This study aimed to test the protective role of coenzyme Q10 against AAS induced cardiotoxicity in adult albino rat models. Twenty-four Wistar albino rats were divided into equal four groups administered ND (nandrolone decanoate) weekly at (20 mg/kg) subcutaneously with and without coenzyme Q10 (10 mg/kg) orally every day for 4 weeks. The results revealed that ND induced a significant increase in the mitochondrial enzyme SDH (succinate dehydrogenase) and mitochondrial calcium level, alteration in the serum level of CK-MB (Creatine PhosphoKinase-MB), and enhancement of apoptosis and fibrosis in the cardiac tissue. Histopathological study of the heart was done. Treatment with Q10 could alleviate the toxic effects induced by ND. | ||||
| Keywords | ||||
| Nandrolone decanoate; Coenzyme Q10; heart; fibrosis; apoptosis | ||||
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