Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection
Rashad, N., Soliman, S., Obaya, A., Elshamy, A., El Helaly, A., Hussien, M., Gomaa, A. (2023). Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection. EKB Journal Management System, 6(1), 1-18. doi: 10.21608/ajgh.2023.187817.1028
Nearmeen Rashad; Sameh Abdelazeem Soliman; Ahmed Ali Obaya; Abdelmonem Mohamed Elshamy; Amira M. El Helaly; Marwa H.S Hussien; Ahmed Fathy Gomaa. "Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection". EKB Journal Management System, 6, 1, 2023, 1-18. doi: 10.21608/ajgh.2023.187817.1028
Rashad, N., Soliman, S., Obaya, A., Elshamy, A., El Helaly, A., Hussien, M., Gomaa, A. (2023). 'Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection', EKB Journal Management System, 6(1), pp. 1-18. doi: 10.21608/ajgh.2023.187817.1028
Rashad, N., Soliman, S., Obaya, A., Elshamy, A., El Helaly, A., Hussien, M., Gomaa, A. Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection. EKB Journal Management System, 2023; 6(1): 1-18. doi: 10.21608/ajgh.2023.187817.1028

Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection

African Journal of Gastroenterology and Hepatology
Volume 6, Issue 1, 2023, Page 1-18  XML PDF (776.86 K)
Document Type: Original Clinical
DOI: 10.21608/ajgh.2023.187817.1028
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Authors
Nearmeen Rashad email 1; Sameh Abdelazeem Soliman2; Ahmed Ali Obaya3; Abdelmonem Mohamed Elshamy4; Amira M. El Helaly5; Marwa H.S Hussien6; Ahmed Fathy Gomaa7
1zagazig
2Internal medicine department, faculty of medicine, zagazig university.
3Clinical Oncology and Nuclear Medicine department ,faculty of medicine,Zagazig University
4Tropical Medicine medicine department,faculty of medicine ,zagazig university
5Clinical pathology department,faculty of medicine ,zagazig unicersity
6Medical Biochemistry Department,faculty of medicine ,zagazig university
7Internal medicine department,faculty of medicine,zagazig University
Abstract
Aims: the current research aimed to investigate LncRNA-MIAT in patients with non-Hodgkin lymphoma (NHL) and to assess its correlation with clinicopathological features and treatment protocols of NHLs among Egyptian patients with Occult hepatitis C virus (HCV) infection (OCI).
Patients & Methods: This study was conducted on 20 patients with NHL and 30 healthy subjects as the control group. All subjects were screened for HCV-RNA in both plasma and PBMCs. RT-PCR determined lncRNA-MIAT.
Results: lncRNA-MIAT relative expression level was upregulated in NHL groups (2.73±0.86) compared to controls (1.06±0.07), P ˂0.001*. Among NHL, patients with OCI (3.2±0.63) had significantly higher levels of lncRNA-MIAT compared to HCV (2.6±1.08) and non-HCV (2.4±0.4), P ˂0.001*. Additionally, the relative expression levels of lncRNA-MIAT were significantly positively correlated with laboratory and clinicopathological features of NHL. Interestingly, concerning the treatment of DLBCL-NHL, there were significantly higher levels of lncRNA-MIAT in no treatment subgroup (n=10, 3.31±0.95) compared to successfully treated subgroups [CHOP (n=7, 1.58±0.34) and R-CHOP (n=3, 11.16±0.21), P ˂0.001*
Conclusions: lncRNA-MIAT level was upregulated in NHL patients, particularly patients with OCI. Thus, circulatory lncRNA-MIAT may serve as a promising non-invasive diagnostic marker for NHL associated with OCI.
Keywords
HCV; lncRNA; MIAT; NHL; DLBCL; Occult hepatitis C; CHOP; RT-PCR; PBMCs; non-invasive
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