Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients
Sorour, A., Ahmed, M., Marzaban, R., Dwedar, R. (2019). Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients. EKB Journal Management System, 28(4), 51-57. doi: 10.21608/ejmm.2019.283212
Ashraf E. Sorour; Marwa A. Ahmed; Raghda N. Marzaban; Reham A. Dwedar. "Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients". EKB Journal Management System, 28, 4, 2019, 51-57. doi: 10.21608/ejmm.2019.283212
Sorour, A., Ahmed, M., Marzaban, R., Dwedar, R. (2019). 'Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients', EKB Journal Management System, 28(4), pp. 51-57. doi: 10.21608/ejmm.2019.283212
Sorour, A., Ahmed, M., Marzaban, R., Dwedar, R. Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients. EKB Journal Management System, 2019; 28(4): 51-57. doi: 10.21608/ejmm.2019.283212

Ascitic Hepatocyte Growth Factor as a marker for Diagnosis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

Egyptian Journal of Medical Microbiology
Volume 28, Issue 4, October 2019, Page 51-57  XML PDF (407.65 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2019.283212
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Authors
Ashraf E. Sorourorcid 1; Marwa A. Ahmed1; Raghda N. Marzaban email 2; Reham A. Dwedar1
1Medical Microbiology & Immunology Department, Faculty of Medicine, Cairo University
2Tropical Medicine, Faculty of medicine, Cairo University
Abstract
Background: Spontaneous bacterial peritonitis (SBP) is a common and potentially lethal complication of decompensated cirrhosis. Hepatocyte growth factor (HGF) is a protein produced by mesenchymal cells, and regulated by different physiological and pathological conditions e.g pregnancy, aging and infections. Objective: This study evaluated ascitic HGF as a local marker in diagnosis of SBP. Methodology: Eighty cirrhotic ascitic patients were divided equally into 40 patients with SBP and 40 without. All involved patients were subjected to assay of ascitic HGF using ELISA technique. Results: Ascitic HGF was significantly related to SBP (P=0.000). The sensitivity and specificity of HGF for differentiating SBP were 80 and 82.5%, respectively, at a cut-off value of 2981.34 pg/ml. There was a significant positive correlation between ascitic HGF and TLC (P=0.018), and transaminases; AST and ALT (P =0.007 and P=0.023 respectively). Conclusion: Ascitic HGF is a reliable minimally invasive biomarker for diagnosis of SBP in cirrhotic patients.
Keywords
Hepatocyte Growth Factor; Spontaneous Bacterial Peritonitis; Ascites; Cirrhosis
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