Study of Serum and Ascitic Fluid Lipopolysaccharide Binding Protein as Potential Markers of Infection in Spontaneous Bacterial Peritonitis | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 238, Volume 90, Issue 1, January 2023, Page 1597-1603 PDF (380.98 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2023.283669 | ||||
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Authors | ||||
Neveen George El-Antouny; Ahmed Abdul Naby Al-Sayed ; Ahmed Abdul-Saboor Mohammed; Heba Shafeak Abd elkhalik | ||||
Abstract | ||||
Background: Hemodynamic instability in cirrhotic individuals and the onset of bacterial infection are both linked to elevated levels of Lipopolysaccharide binding protein (LBP). Objective: The aim of the current work was to evaluate the significance of lipopolysaccharide binding protein (LBP) level in serum and ascitic fluid in spontaneous bacterial peritonitis (SBP) patients as a marker for infection. Patients and Methods:A total of 112 patients were enrolled in this case control study and were split into two categories: Group (A):consisted of 56 individuals with chronic liver disease (CLD) having ascites exacerbated by spontaneous bacterial peritonitis (SBP) through clinical and laboratory examinations. Group (B): consisted of 56 individuals with chronic liver disease (CLD) and ascites who had no detectable infection based on clinical and laboratory tests. Results: In group A; significant positive correlations were found between serum LBP, HB, and total protein. Also, a negative remarkable correlation between serum LBP, INR, PTT, PT, serum creatinine, direct bilirubin, total bilirubin, PLT, and ascitic fluid LBP. In group (B);significant positive correlations were found between serum LBP, AST, and TLC. Also, a negative remarkable correlation between serum LBP, PTT, serum urea, serum creatinine, and total bilirubin. Conclusion: It could be concluded that serum LBP demonstrated a highly significant difference between the two groups with a substantial difference as regard the diagnosis of spontaneous bacterial peritonitis, both in terms of sensitivity and specificity. Serum LBP may be considered as a diagnostic tool for SBP in cirrhotic patients with ascites. | ||||
Keywords | ||||
Lipopolysaccharide Binding Protein; Spontaneous Bacterial Peritonitis | ||||
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