Diagnostic Value of Interleukin 1 Receptor Antagonist (IL-1RA) in Children with Refractory Epilepsy | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 240, Volume 90, Issue 1, January 2023, Page 1611-1616 PDF (410.22 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.283671 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Rhoyda Essam Moustafa Atteq  ; Ahmed Galal Siam; Doaa Metwaly AbdElmonem; Amr I. Risha
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| Abstract | ||||
| Background: Clinical studies have shown that prolonged seizures result in increased cytokine production in the central nervous system. Aim of work: To focus on diagnostic value of interleukin-1 receptor antagonists in refractory epilepsy. Patients and methods: This case-control investigation was done in Pediatric Neurology Unit and Pediatric Neurology Clinics, Faculty of Medicine, Zagazig University. Children were classified into: patient group: 59 children with refractory epilepsy aged between 1 year and 16 years old and control group: 59 healthy children who are age and sex corresponded to the patient population. Serum level of IL-1Ra was assessed. Results: There is significant higher value of plasma of interleukin1 receptor antagonist in studied refractory epilepsy group compared to the healthy control group. Conclusion: Interleukin-1 receptor antagonist can differentiate the control group and the seizure group. | ||||
| Keywords | ||||
| IL-1RA; Refractory Epilepsy; diagnosis | ||||
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