Relation of Three-Dimensional Circumferential Strain Rate to Mediators of Intestinal Dysbiosis in Children with Chronic Systolic Dysfunction
Kotby, A., El Ganzourya, M., Habeeb, N., El Samman, N., Soliman, N. (2023). Relation of Three-Dimensional Circumferential Strain Rate to Mediators of Intestinal Dysbiosis in Children with Chronic Systolic Dysfunction. EKB Journal Management System, 90(1), 1640-1644. doi: 10.21608/ejhm.2023.283676
Alyaa A. Kotby; Mona M. El Ganzourya; Nevin M. Habeeb; Nora El Samman; Nanies M.S. Soliman. "Relation of Three-Dimensional Circumferential Strain Rate to Mediators of Intestinal Dysbiosis in Children with Chronic Systolic Dysfunction". EKB Journal Management System, 90, 1, 2023, 1640-1644. doi: 10.21608/ejhm.2023.283676
Kotby, A., El Ganzourya, M., Habeeb, N., El Samman, N., Soliman, N. (2023). 'Relation of Three-Dimensional Circumferential Strain Rate to Mediators of Intestinal Dysbiosis in Children with Chronic Systolic Dysfunction', EKB Journal Management System, 90(1), pp. 1640-1644. doi: 10.21608/ejhm.2023.283676
Kotby, A., El Ganzourya, M., Habeeb, N., El Samman, N., Soliman, N. Relation of Three-Dimensional Circumferential Strain Rate to Mediators of Intestinal Dysbiosis in Children with Chronic Systolic Dysfunction. EKB Journal Management System, 2023; 90(1): 1640-1644. doi: 10.21608/ejhm.2023.283676

Relation of Three-Dimensional Circumferential Strain Rate to Mediators of Intestinal Dysbiosis in Children with Chronic Systolic Dysfunction

The Egyptian Journal of Hospital Medicine
Article 245, Volume 90, Issue 1, January 2023, Page 1640-1644  XML PDF (477.46 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.283676
View on SCiNiTO View on SCiNiTO
Authors
Alyaa A. Kotby; Mona M. El Ganzourya; Nevin M. Habeeb; Nora El Samman; Nanies M.S. Soliman email
Abstract
Background: Changes that may occur in intestinal microbiota have been shown to result in abnormal levels of intermediates, which can adversely affect the cardiovascular status.
Objectives: We aimed to study trimethylamine-N-oxide level (TMAO) in patients with chronic systolic dysfunction as a marker of intestinal dysbiosis and correlate it with cardiac status and echocardiographic findings.
Patients and methods: Twenty-five children with chronic cardiac dysfunction underwent sample collection for TMAO level. They have been compared to twenty-five age and sex-matched controls. Patients were assessed with conventional transthoracic echocardiography and three-dimensional speckle-derived strain imaging. 
Results: Median age was 4.5 years. Patients had significantly lower ejection fraction (EF) and fractional shortening (FS) (P <0.001), and lower global, radial, circumferential and longitudinal 3-D strain rates (p < 0.001). TMAO was significantly higher in patients (p < 0.05). Best cut-off value was >6.2 um with sensitivity= 96% and specificity= 100%. TMAO correlated with Ross class, hospitalization rate as well as EF, FS, LV dimensions and volumes, and 3 D circumferential and radial strain rates. Linear regression analysis showed circumferential strain being an independent predictor of TMAO levels in the blood.
Conclusions: TMAO levels are increased in patients with chronic systolic dysfunction, which is related to their clinical status as well as their echocardiographic parameters. Three-dimensional circumferential strain rate seems to be an independent predictor of TMAO levels.
 
Keywords
Plasma trimethylamine-N-oxide; Three-dimensional strain rate; Dilated cardiomyopathy
Statistics
Article View: 90
PDF Download: 201