Adherence to Sorafenib Therapy Is Not Affected by Treatment-Related Side Effects or Demographic Characteristics of Iraqi Patients with Hepatocellular Carcinoma | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 254, Volume 90, Issue 1, January 2023, Page 1690-1679 PDF (763.73 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.283685 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Tuqa Haitham Qasim; Mohammed Abdul-Hassan Jabarah AL-Zobaidy  ; Mazin Jody
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| Abstract | ||||
| Introduction: Sorafenib is an orally active multiple kinase inhibitor for the treatment of advanced renal cell carcinoma and hepatocellular carcinoma (HCC) patients. However, measuring the experience of patient-reported symptoms may provide additional information to compare the efficacy and toxicity of treatments. Objective: The aim of the current study was to investigate the association between hepatocellular carcinoma patients’ adherence to treatment and their demographic characteristics. Patients and methods: An open-label cross-sectional study was conducted at the Oncology Teaching Hospital, Al-Amal Hospital, Imam Al-Kadhimin Medical City in Baghdad, Iraq, from November 2021 to July 2022. A total of 52 patients taking sorafenib for their HCC were recruited in our study. Adherence to treatment was assessed using Morisky Medication Adherence Scale. Results: A total of 52 patients were enrolled in current study. Fatigue was the most common adverse event as it was experienced by 90.4% of participants, followed by anorexia, anemia, nausea and diarrhea (71.2%, 67.3%, 65.4%, and 59.6%, respectively), while only 26.9% of participants had vomiting. In addition, all participants showed low-moderate adherence to treatment. Also, there was non-significant association between demographic data of patients or treatment-related adverse effects. Conclusion: Patients with hepatocellular carcinoma on sorafenib treatment exhibit low-moderate levels of adherence. The latter had not affected by sorafenib-related adverse effects or demographic characteristics of patients. | ||||
| Keywords | ||||
| Adherence; Adverse effects; Hepatocellular carcinoma; Multikinase inhibitor; Sorafenib; Cross sectional study; University of Baghdad; Iraq | ||||
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