A Multi Compartmental model for Targeted Drug Delivery Based on Internet of Biological NanoThings
R.Kamal, I., M. Abd El-Atty, S., El-Zoghdy, S., F. Soliman, R. (2023). A Multi Compartmental model for Targeted Drug Delivery Based on Internet of Biological NanoThings. EKB Journal Management System, 32(1), 15-23. doi: 10.21608/mjeer.2023.283913
Islam R.Kamal; Saied M. Abd El-Atty; S. F. El-Zoghdy; Randa F. Soliman. "A Multi Compartmental model for Targeted Drug Delivery Based on Internet of Biological NanoThings". EKB Journal Management System, 32, 1, 2023, 15-23. doi: 10.21608/mjeer.2023.283913
R.Kamal, I., M. Abd El-Atty, S., El-Zoghdy, S., F. Soliman, R. (2023). 'A Multi Compartmental model for Targeted Drug Delivery Based on Internet of Biological NanoThings', EKB Journal Management System, 32(1), pp. 15-23. doi: 10.21608/mjeer.2023.283913
R.Kamal, I., M. Abd El-Atty, S., El-Zoghdy, S., F. Soliman, R. A Multi Compartmental model for Targeted Drug Delivery Based on Internet of Biological NanoThings. EKB Journal Management System, 2023; 32(1): 15-23. doi: 10.21608/mjeer.2023.283913

A Multi Compartmental model for Targeted Drug Delivery Based on Internet of Biological NanoThings

Menoufia Journal of Electronic Engineering Research
Article 3, Volume 32, Issue 1, January 2023, Page 15-23  XML PDF (1.17 MB)
DOI: 10.21608/mjeer.2023.283913
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Authors
Islam R.Kamal1; Saied M. Abd El-Atty2; S. F. El-Zoghdy3; Randa F. Soliman4
1Department of pure mathematics and Computer Science, Faculty of Science, Menoufia University Egypt and Department of Computer Science, Modern Academy at Maadi, Egypt
2Department of Electronics and Electrical Communications Engineering, Faculty of Electronic Engineering, Menoufia University, Menouf 32952, Egypt.
3Department of Mathematics and Computer Science, Faculty of Science Menoufia University, Shebin El-Koom , Egypt.
4Machine Intelligence Department, Faculty of Artificial Intelligence, Menoufia University, Shebin El-Koom, Egypt.
Abstract
The authors propose a multi-compartmental model based on molecular communication (MC) technology for drug delivery to the malignant cell without affecting healthy cells in the patient's body. The medical personnel can transfer/control the required drug to the targeted cell with the help of a group of bio-nanomachines connected to the Internet of biological Nano Things (IoBNT) and a bio-cyber interface in both the forward and reverse directions. The proposed model consists of a set of multi-differential equations that are used to identify molecular communication among bio-nanomachines and quantify drug concentration to the targeted cell. Unlike conventional compartmental models, the proposed model can deliver the desired drug to the targeted cell by accounting for extracellular and intracellular tumor compartments, resulting in fewer therapeutic doses with improved efficacy. Simulations were also carried out to evaluate the performance of proposed multi-compartmental model with changing the physical parameters.
Keywords
Compartmental model; Drug delivery; Bio-nanomachine; Molecular communications; Internet of Bio-NanoThings
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