Progranulin Versus Procalcitonin as a Novel Biomarker in Diagnosis of Early-Onset Neonatal Sepsis
Abd Almonaem, E., Elfiky, O., Ameen, S., Elsharnoby, A. (2023). Progranulin Versus Procalcitonin as a Novel Biomarker in Diagnosis of Early-Onset Neonatal Sepsis. EKB Journal Management System, 40(2), 379-388. doi: 10.21608/bmfj.2023.171497.1698
Eman Rateb Abd Almonaem; Osama Abu El fotoh Elfiky; Seham Gouda Ameen; Alaa Elsharnoby. "Progranulin Versus Procalcitonin as a Novel Biomarker in Diagnosis of Early-Onset Neonatal Sepsis". EKB Journal Management System, 40, 2, 2023, 379-388. doi: 10.21608/bmfj.2023.171497.1698
Abd Almonaem, E., Elfiky, O., Ameen, S., Elsharnoby, A. (2023). 'Progranulin Versus Procalcitonin as a Novel Biomarker in Diagnosis of Early-Onset Neonatal Sepsis', EKB Journal Management System, 40(2), pp. 379-388. doi: 10.21608/bmfj.2023.171497.1698
Abd Almonaem, E., Elfiky, O., Ameen, S., Elsharnoby, A. Progranulin Versus Procalcitonin as a Novel Biomarker in Diagnosis of Early-Onset Neonatal Sepsis. EKB Journal Management System, 2023; 40(2): 379-388. doi: 10.21608/bmfj.2023.171497.1698

Progranulin Versus Procalcitonin as a Novel Biomarker in Diagnosis of Early-Onset Neonatal Sepsis

Benha Medical Journal
Article 6, Volume 40, Issue 2, September and October 2023, Page 379-388  XML PDF (660.54 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.171497.1698
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Authors
Eman Rateb Abd Almonaem1; Osama Abu El fotoh Elfiky1; Seham Gouda Ameen2; Alaa Elsharnoby email 1
1Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt.
2Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
Abstract
Background: Neonatal sepsis is the third most common reason for neonatal mortality, which is a serious health issue. Early diagnosis can help these neonates have better outcomes. Objective: Progranulin (PGRN) and procalcitonin (PCT) were evaluated for their diagnostic utility in early-onset sepsis (EOS). Methods: The neonates in this study were born at ≥ 34 weeks gestation and hospitalized to the Neonatal Intensive Care Unit within the first 72 hours of life. The infected group contained 50 infants, whereas the uninfected group included 60 neonates. All infants had thorough clinical evaluations and lab testing. The levels of procalcitonin and progranulin in the serum were determined using ELISA. Results: At the three-time intervals, there was no noticeable difference between the groups in terms of CRP. With a p-value of 0.003, PCT was statistically more significant in the infected group (0.990.50 ng/dl) than in the uninfected group (0.40.44 ng/dl) during the 1-24 h interval, but there was no difference at the 24-48 h or 49-72 h intervals. At each of the three-time intervals when the infected and uninfected groups were compared, PGRN was considerably higher in the infected group (p 0.001). Furthermore, PGRN was statistically greater during 49-72 h intervals in the infected group compared to 1-24 h and 25-48 breaks (p=0.004). However, at various intervals, the PGRN levels in the uninfected group did not vary significantly (p=0.053). Conclusion: PGRN was found in newborn sepsis with an early onset and may be helpful as a biomarker for diagnosis.
Keywords
Progranulin; procalcitonin; biomarker; neonatal; sepsis
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