EFFECT OF ESTRADIOL, IMIPRAMINE AND FLUOXETINE ON BRAIN SEROTONIN LEVELS IN OVARIECTOMIZED-INDUCED OSTEOPOROTIC RATS | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 9, Volume 55, Issue 1, March 2017, Page 118-127 PDF (608.49 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2017.28413 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Nora Zakaria | ||||
| Armed Forces Medical Complex- KobryEl-Qobba, Ministry of Defense | ||||
| Abstract | ||||
| Aim: The present study aimed to determine the effect of Estradiol, Imipramine and Fluoxetine on brain serotonin levels in ovariectomized-induced osteoporotic rats and to investigate the effect of previous treatments on Electron Microscope results in rats. Methods: Rats were subjected to bilateral ovariectomy. After 2 weeks from operations, rats were treated with Estradiol, Imipramine and Fluoxetine for 14 days. At the end of 6 weeks animals were sacrificed and serotonin levels of brain tissue were determined. Electron microscope examination of femoral bone was also performed. Results: Treatment with Estradiol, Imipramine and Fluoxetine could treat depressive symptoms caused by ovariectomy which was observed in brain serotonin levels. Treatments could decrease the levels of brain serotonin by 28.73%, 35.25% and 32.14% respectively. Regarding Electron microscope, imipramine could partially improve bone structure while estradiol and fluoxetine could significantly restore bone mass compared to the corresponding osteoporosis group. Conclusion: In conclusion, Estradiol, imipramine and fluoxetine could treat depressive symptoms caused by ovariectomy in rats. Treatments have also shown restorative effects on bone structure in ovariectomized-induced osteoporotic rats. | ||||
| Keywords | ||||
| tricyclic antidepressants; selective serotonin reuptake inhibitors; ovariectomized-induced osteoporosis; estradiol; imipramine; fluoxetine; serotonin | ||||
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