Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives
Nassar, I., Abdel Rahman, A., Adel Khalek, H., Sharaf, A., El-Sayed, W. (2023). Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives. EKB Journal Management System, 66(10), 621-637. doi: 10.21608/ejchem.2023.172380.7187
Ibrahim F. Nassar; Adel A. H. Abdel Rahman; Heba A. Adel Khalek; Afrah Sharaf; Wael A. El-Sayed. "Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives". EKB Journal Management System, 66, 10, 2023, 621-637. doi: 10.21608/ejchem.2023.172380.7187
Nassar, I., Abdel Rahman, A., Adel Khalek, H., Sharaf, A., El-Sayed, W. (2023). 'Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives', EKB Journal Management System, 66(10), pp. 621-637. doi: 10.21608/ejchem.2023.172380.7187
Nassar, I., Abdel Rahman, A., Adel Khalek, H., Sharaf, A., El-Sayed, W. Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives. EKB Journal Management System, 2023; 66(10): 621-637. doi: 10.21608/ejchem.2023.172380.7187

Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives

Egyptian Journal of Chemistry
Volume 66, Issue 10, October 2023, Page 621-637  XML PDF (271.16 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.172380.7187
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Authors
Ibrahim F. Nassar email orcid 1; Adel A. H. Abdel Rahmanorcid 2; Heba A. Adel Khalek2; Afrah Sharaf3; Wael A. El-Sayed4, 5
1Department of Chemistry, Faculty of Specific Education, Ain Shams University, Abassia, Cairo, Egypt
2Chemistry Department, Faculty of Science, Menofia University, Shbien El-Kom, Egypt
3Department of Chemistry, College of Science, Jazan University, Kingdom of Saudi Arabia
4Department of Chemistry, College of Science, Qassim University, Buraydah, Saudi Arabia
5Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt
Abstract
New substituted pyrimidine, pyrazole, pyridine and pyrrole derivatives were synthesized from an unsaturated arylacetylmine key derivative via cyclization reaction with the suitable corresponding reagent and their structures were characterized by elemental and spectral analyses. The anticancer, antimicrobial and anti-Hepatities B activity of the synthesized compounds were studied against a panel of cells and microbes. The results showed moderate to high activities for most of the tested compounds.
Keywords
Pyrimidine; pyridine; pyrazole; antimicrobial; antitumor; antiviral; anti-Hepatities B
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