Residues Depletion of Doxycycline in Rabbit Tissues Using HPLC | ||||
| Zagazig Veterinary Journal | ||||
| Article 5, Volume 43, Issue 3, December 2015, Page 37-45 PDF (658.33 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zvjz.2015.28440 | ||||
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| Authors | ||||
| Maha S. Abdel-Hafeez1; Ahmed A. Said2; Sameh M. El-Nabtity2; Elham A. Mobarez1; Eslam E. Hamed3 | ||||
| 1Chemistry Department, Animal Health Research Institute, Dokki, Giza, Egypt | ||||
| 2Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt | ||||
| 3Central Laboratory, Faculty of Veterinary Medicine, Zagazig University | ||||
| Abstract | ||||
| This work was performed to quantitatively determine doxycycline residues in different tissues of rabbits (kidneys, spleen, liver, muscles, heart and lungs) and sera following multiple oral doses of the drug using High Performance Liquid Chromatography. Moreover, the study aimed to estimate the withdrawal time of this drug in rabbit tissues. Twenty five healthy male New Zealand rabbits ranging from 2-2.5 kg body weight were used. Twenty one rabbits were given doxycycline directly into the stomach at a dosage of 10 mg/kg BW once daily for five successive days. Samples were analyzed at 1st, 3rd, 5th, 7th, 9th, 15th and 21st day after last oral dose. The results indicated a widespread distribution of doxycycline in the samples, which remained within the detectable limit till the 3rd day in most tested tissues. While in kidneys, spleen and liver, doxycycline remained till the 5th day following the last oral administration of the drug. Therefore, it is recommended that rabbits treated with doxycycline must be slaughtered after the fifth day of drug administration to be safe for human consumption. | ||||
| Keywords | ||||
| residues; depletion; Doxycycline; Rabbits; HPLC | ||||
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