Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature
Ahmed, N., Abuzahra, M., Sarhan, M., Zaghary, W. (2023). Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature. EKB Journal Management System, 66(10), 331-353. doi: 10.21608/ejchem.2023.183386.7384
Nesreen Said Ahmed; Manar Abuzahra; Mona Sarhan; Wafaa Abdou Zaghary. "Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature". EKB Journal Management System, 66, 10, 2023, 331-353. doi: 10.21608/ejchem.2023.183386.7384
Ahmed, N., Abuzahra, M., Sarhan, M., Zaghary, W. (2023). 'Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature', EKB Journal Management System, 66(10), pp. 331-353. doi: 10.21608/ejchem.2023.183386.7384
Ahmed, N., Abuzahra, M., Sarhan, M., Zaghary, W. Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature. EKB Journal Management System, 2023; 66(10): 331-353. doi: 10.21608/ejchem.2023.183386.7384

Synthesis and Anticancer Potentials of 1,8-Naphthyridine Analogues: A Review of Literature

Egyptian Journal of Chemistry
Volume 66, Issue 10, October 2023, Page 331-353  XML PDF (7.82 MB)
Document Type: Review Articles
DOI: 10.21608/ejchem.2023.183386.7384
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Authors
Nesreen Said Ahmed email orcid 1; Manar Abuzahra2; Mona Sarhan3; Wafaa Abdou Zaghary4
1Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Division, National Research Center,Cairo, Egypt
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
3Labelled Compounds Department, Hot Lab Centre, Atomic Energy Authority, Cairo 13759, Egypt.
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt.
Abstract
This review focuses on the potential of 1,8-Naphthyridine derivatives in the chemotherapeutic cancer treatment and highlights significant recent progress in the synthetic development of 1,8-naphthyridines as antitumor agents. The present review provide the classical (Skraup, Doebner-Von-Miller, Gould– Jacob, Meth-Cohn, Friedlander, Pfitzinger, Knorr and Conard Limpach, Combes, Niementowski and Pictet-Spengler) and green approaches (metal free ionic liquid mediated reactions, microwave irradiation reactions) for synthesis of 1,8-naphthyridines. 1,8-naphthyridine derivatives which exert their anticancer activity via several mechanisms like apoptosis inducing agents, cell cycle arrest, topoisomerase I and II inhibitors, tubulin polymerization inhibitors, protein kinase inhibitors, intercalation with DNA, angiogenesis inhibitors, Ras protein inhibitors and telomerase inhibitors, are highlighted with proper synthetic methods, SAR studies and molecular docking.
Keywords
1,8-Naphthyridine; Anticancer agents; Structure-activity relationship; Human cancer cell line; Molecular modelling
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