Comparison Between Er: Yag and Co2 Ablative Fractional Lasers in The Treatment of Keloid and Hypertrophic Scars: Histopathological, Immuno-Histochemical and Ultrastructural Study
Elsaid, D., Al-Tawel, A., Sabry, H., Hasby, E. (2023). Comparison Between Er: Yag and Co2 Ablative Fractional Lasers in The Treatment of Keloid and Hypertrophic Scars: Histopathological, Immuno-Histochemical and Ultrastructural Study. EKB Journal Management System, 8(2), 65-79. doi: 10.21608/bjas.2023.188236.1038
Dina Elsaid; Abdel-Aziz Al-Tawel; Hanan Sabry; Eiman Hasby. "Comparison Between Er: Yag and Co2 Ablative Fractional Lasers in The Treatment of Keloid and Hypertrophic Scars: Histopathological, Immuno-Histochemical and Ultrastructural Study". EKB Journal Management System, 8, 2, 2023, 65-79. doi: 10.21608/bjas.2023.188236.1038
Elsaid, D., Al-Tawel, A., Sabry, H., Hasby, E. (2023). 'Comparison Between Er: Yag and Co2 Ablative Fractional Lasers in The Treatment of Keloid and Hypertrophic Scars: Histopathological, Immuno-Histochemical and Ultrastructural Study', EKB Journal Management System, 8(2), pp. 65-79. doi: 10.21608/bjas.2023.188236.1038
Elsaid, D., Al-Tawel, A., Sabry, H., Hasby, E. Comparison Between Er: Yag and Co2 Ablative Fractional Lasers in The Treatment of Keloid and Hypertrophic Scars: Histopathological, Immuno-Histochemical and Ultrastructural Study. EKB Journal Management System, 2023; 8(2): 65-79. doi: 10.21608/bjas.2023.188236.1038

Comparison Between Er: Yag and Co2 Ablative Fractional Lasers in The Treatment of Keloid and Hypertrophic Scars: Histopathological, Immuno-Histochemical and Ultrastructural Study

Benha Journal of Applied Sciences
Article 10, Volume 8, Issue 2, February 2023, Page 65-79  XML PDF (1023.07 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2023.188236.1038
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Authors
Dina Elsaid email 1; Abdel-Aziz Al-Tawel1; Hanan Sabry1; Eiman Hasby2
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha University(
2Pathology Dept., Faculty of Medicine, Benha University
Abstract
Background: Scarring is a frequent occurrence, since it results from skin damage in individuals of all ages. This work aimed compare clinical results and effect on histopathological architecture and expression of CTGF of the ablative fractional 10,600-nm CO2 and 2,940 nm Er:YAG lasers in keloid and hypertrophic scars treatment. Methods: that randomized, prospective, double-blinded comparative study included 60 individuals (Fitzpatrick skin type II to V), that are diagnosed clinically and histopathologically with hypertrophic scars. Those were split into 2 groups; 30 patients in group I (Fractional Er:YAG laser), and 30 patients in group II (fractional CO2 laser). Results: A substantial decrease in post treatment VSS with fractional ablative Er:YAG and Co2 lasers mostly as a result of improved vascularity, pliability and to a lesser extent in height with Er:YAG ,while after CO2 improvement was significant in height and pliability only. Histopathological examination of skin biopsies in current study, showed that there were increased thickness of epidermis and irregular collagen bands replacement with parallel new collagen fibril organisation after fractional ablative Er:Yag. Immunohistochemical staining of CTGF showed significant reduction 6 months follwoing fractional Erbium YAG and CO2 laser treatment with prominent decrease after Fr Er: YAG. Conclusions: Fractional ablative lasers including both CO2 and Er:YAG have combined impressive ablative laser results with greater protection profile of nonablative lasers. Fractional ablative Er:YAG laser mainly improve vascularity and pliability of hypertrophic scars while Co2 improvement was significant in height and pliability.
Background: Scarring is a frequent occurrence, since it results from skin damage in individuals of all ages. This work aimed compare clinical results and effect on histopathological architecture and expression of CTGF of the ablative fractional 10,600-nm CO2 and 2,940 nm Er:YAG lasers in keloid and hypertrophic scars treatment. Methods: that randomized, prospective, double-blinded comparative study included 60 individuals (Fitzpatrick skin type II to V), that are diagnosed clinically and histopathologically with hypertrophic scars. Those were split into 2 groups; 30 patients in group I (Fractional Er:YAG laser), and 30 patients in group II (fractional CO2 laser). Results: A substantial decrease in post treatment VSS with fractional ablative Er:YAG and Co2 lasers mostly as a result of improved vascularity, pliability and to a lesser extent in height with Er:YAG ,while after CO2 improvement was significant in height and pliability only. Histopathological examination of skin biopsies in current study, showed that there were increased thickness of epidermis and irregular collagen bands replacement with parallel new collagen fibril organisation after fractional ablative Er:Yag. Immunohistochemical staining of CTGF showed significant reduction 6 months follwoing fractional Erbium YAG and CO2 laser treatment with prominent decrease after Fr Er: YAG. Conclusions: Fractional ablative lasers including both CO2 and Er:YAG have combined impressive ablative laser results with greater protection profile of nonablative lasers. Fractional ablative Er:YAG laser mainly improve vascularity and pliability of hypertrophic scars while Co2 improvement was significant in height and pliability.
Keywords
Er: Yag; CO2 Ablative Fractional Lasers; Keloid; Hypertrophic Scars
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