Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt
Ghazal, A., EL Ghazawy, I., Metwally, D., Mohammed, F., ELBatouti, G. (2023). Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt. EKB Journal Management System, 4(2), 418-427. doi: 10.21608/mid.2023.189097.1454
Abeer Ghazal; Ibtisam EL Ghazawy; Dalia El Sayed Metwally; Fatma Mohammed; Gihan ELBatouti. "Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt". EKB Journal Management System, 4, 2, 2023, 418-427. doi: 10.21608/mid.2023.189097.1454
Ghazal, A., EL Ghazawy, I., Metwally, D., Mohammed, F., ELBatouti, G. (2023). 'Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt', EKB Journal Management System, 4(2), pp. 418-427. doi: 10.21608/mid.2023.189097.1454
Ghazal, A., EL Ghazawy, I., Metwally, D., Mohammed, F., ELBatouti, G. Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt. EKB Journal Management System, 2023; 4(2): 418-427. doi: 10.21608/mid.2023.189097.1454

Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt

Microbes and Infectious Diseases
Article 11, Volume 4, Issue 2, May 2023, Page 418-427  XML PDF (571.78 K)
Document Type: Original Article
DOI: 10.21608/mid.2023.189097.1454
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Authors
Abeer Ghazal1; Ibtisam EL Ghazawy1; Dalia El Sayed Metwallyorcid 2; Fatma Mohammed3; Gihan ELBatouti email orcid 4
1Department of Molecular and Diagnostic Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt
2Department of Molecular and Diagnostic Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt.
3Pharmacy Department, Alexandria Hepatology, Gastroenterology and Infectious Disease Hospital, Alexandria, Egypt
4Department of Microbiology and Immunology, Faculty of Pharmacy, Pharos University in Alexandria, Egypt
Abstract
Background: Humanimmunodeficiencyvirus (HIV) infection is a global health issue. Upon invasion, the virus induces many inflammatory cytokines; especially interferon-γ induced protein 10 (IP-10). The aim of our study was to detect and compare the serum IP- 10 levels in HIV mono- infected, hepatitis C virus (HCV) mono- infected patients, and HIV co-infected patients with HCV. Methods: The study included 30 HIV patients (15 mono- infected and 15 co-infected with HCV), 15 HCV infected patients and15 healthy controls. HIV RNA, HCV RNA, CD4+T cell counts, IP-10 levels and Fibrous -4 score were estimated. Results: The mean value for HIV PCR was 1.04*104 ± 3.86*104 in HIV co-infected patients and 4.14*107 ± 1.58*108 in HIV mono-infected patients. The highest mean value for FIB-4 scores and CD4+T cell counts were among HIV co-infected patients; 1.56 ± 2.17 and 432.80 ± 294.83 respectively. HCV mono-infected patients revealed the highest IP-10 mean value; 472.0±235.28.  No significant difference was found in HIV co-infected (p < /em>= 0.806, 0.327) nor HIV mono-infected patients (p < /em>=0.244,0.581) regarding the relation between CD4+T counts 5(> 400 or < 400) with the IP-10 levels and FIB-4 scores respectively. Conclusions: High IP-10 levels were associated with low CD4 cell count in HIV mono and co-infected patients. IP-10 secretion may be related to HIV pathogenesis and immune depletion. HIV/HCV co-infection did not influence HIV disease progression.
Keywords
CD4+T cell; Co-infection; Highly Active Antiretroviral Therapy; Human Immunodeficiency virus; Interferon-γ induced protein- 10
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