Association of Human Cytomegalovirus with Hepatitis C Virus Infections and Its Impact on Antiviral Therapy
Shoeb, S., Abd El-Hameid, A., Ismael, S., Ahmed, D. (2018). Association of Human Cytomegalovirus with Hepatitis C Virus Infections and Its Impact on Antiviral Therapy. EKB Journal Management System, 27(1), 51-56. doi: 10.21608/ejmm.2018.285147
Samira A. Shoeb; Ashraf E. Abd El-Hameid; Sohier A. Ismael; Duaa D. Ahmed. "Association of Human Cytomegalovirus with Hepatitis C Virus Infections and Its Impact on Antiviral Therapy". EKB Journal Management System, 27, 1, 2018, 51-56. doi: 10.21608/ejmm.2018.285147
Shoeb, S., Abd El-Hameid, A., Ismael, S., Ahmed, D. (2018). 'Association of Human Cytomegalovirus with Hepatitis C Virus Infections and Its Impact on Antiviral Therapy', EKB Journal Management System, 27(1), pp. 51-56. doi: 10.21608/ejmm.2018.285147
Shoeb, S., Abd El-Hameid, A., Ismael, S., Ahmed, D. Association of Human Cytomegalovirus with Hepatitis C Virus Infections and Its Impact on Antiviral Therapy. EKB Journal Management System, 2018; 27(1): 51-56. doi: 10.21608/ejmm.2018.285147

Association of Human Cytomegalovirus with Hepatitis C Virus Infections and Its Impact on Antiviral Therapy

Egyptian Journal of Medical Microbiology
Volume 27, Issue 1, January 2018, Page 51-56  XML PDF (313.92 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2018.285147
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Authors
Samira A. Shoeb1; Ashraf E. Abd El-Hameid1; Sohier A. Ismael2; Duaa D. Ahmed email 2
1Medical Microbiology & Immunology Faculty of Medicine, Cairo University, Cairo, Egypt
2Hepatology & Gastroenterology National Hepatology & Tropical Medicine Research Institute (NHTMRI),Cairo,Egypt
Abstract
Background: CMV infection enhances HCV pathogenesis by preventing the normal mechanisms responsible for HCV clearance, thus playing vital role in HCV persistence and pathogenicity. Objective: To examine the effect of HCV - CMV coinfection on outcome of treatment with pegylated interferon alpha and Ribavirin in chronic HCV patients. Methodology: The study included of 50 cases selected from Outpatient Clinic of The National Hepatology and Tropical Medicine Research Institute (NHTMRI). Two groups were classified group 1 (positive HCV PCR and negative CMV Ig G) and included 15 patients versus group 2 (positive HCV PCR and positive CMV Ig G) and included 35 patients. Results: The non responders to treatment were higher in group 2 (65.7 %) than in group 1 (53.3 %) but with no statistical significance. Conclusion: CMV co-infection may influence the HCV treatment outcome, despite it failed to have statistical significance.
Keywords
Human Cytomegalovirus; Hepatitis C; Antiviral Therapy
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