The Effect of Dual Trigger of Oocyte Maturation with Gonadotropin-Releasing Hormone Agonist and Low-Dose Human Chorionic Gonadotropin on Pregnancy Rate in Women at Risk of Ovarian Hyperstimulation Syndrome
Abdel-Aal, M., Wafa, Y., El Shershaby, S. (2019). The Effect of Dual Trigger of Oocyte Maturation with Gonadotropin-Releasing Hormone Agonist and Low-Dose Human Chorionic Gonadotropin on Pregnancy Rate in Women at Risk of Ovarian Hyperstimulation Syndrome. EKB Journal Management System, 74(8), 1687-1697. doi: 10.21608/ejhm.2019.28520
Marwa Salah Elsayed Abdel-Aal; Yehia Abdel Salam Wafa; Shokry Abdel Azeim El Shershaby. "The Effect of Dual Trigger of Oocyte Maturation with Gonadotropin-Releasing Hormone Agonist and Low-Dose Human Chorionic Gonadotropin on Pregnancy Rate in Women at Risk of Ovarian Hyperstimulation Syndrome". EKB Journal Management System, 74, 8, 2019, 1687-1697. doi: 10.21608/ejhm.2019.28520
Abdel-Aal, M., Wafa, Y., El Shershaby, S. (2019). 'The Effect of Dual Trigger of Oocyte Maturation with Gonadotropin-Releasing Hormone Agonist and Low-Dose Human Chorionic Gonadotropin on Pregnancy Rate in Women at Risk of Ovarian Hyperstimulation Syndrome', EKB Journal Management System, 74(8), pp. 1687-1697. doi: 10.21608/ejhm.2019.28520
Abdel-Aal, M., Wafa, Y., El Shershaby, S. The Effect of Dual Trigger of Oocyte Maturation with Gonadotropin-Releasing Hormone Agonist and Low-Dose Human Chorionic Gonadotropin on Pregnancy Rate in Women at Risk of Ovarian Hyperstimulation Syndrome. EKB Journal Management System, 2019; 74(8): 1687-1697. doi: 10.21608/ejhm.2019.28520

The Effect of Dual Trigger of Oocyte Maturation with Gonadotropin-Releasing Hormone Agonist and Low-Dose Human Chorionic Gonadotropin on Pregnancy Rate in Women at Risk of Ovarian Hyperstimulation Syndrome

The Egyptian Journal of Hospital Medicine
Article 2, Volume 74, Issue 8, January 2019, Page 1687-1697  XML PDF (520.67 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.28520
View on SCiNiTO View on SCiNiTO
Authors
Marwa Salah Elsayed Abdel-Aal email 1; Yehia Abdel Salam Wafa1; Shokry Abdel Azeim El Shershaby2
1Obstetrics and Gynecology Departments, Faculty of Medicine
2International Islamic Center for Population Studies and Research (Assisted Reproduction Unit) Al-Azhar University
Abstract
Background: the purpose of this study was to compare rates of ovarian hyperstimulation syndrome (OHSS) and the pregnancy outcome after using gonadotropin-releasing hormone agonists (GnRHa) alone and GnRHa in combination with low-dose human chorionic gonadotropin (hCG, dual trigger) for final oocyte maturation in women undergoing controlled ovarian hyperstimulation (COH). Patients and Methods: the study included 150 female patients with high risk of OHSS occurrence who were allocated by the Computer-based randomization method into two groups with 75 patients in each arm, Group I received GnRHa trigger and Group II received dual trigger (GnRHa + low-dose (1500 IU) hCG trigger). Results: Our study showed that the incidence of OHSS was higher after dual trigger than GnRHa trigger but with no statistically significant difference (8.0 vs 1.33 %, p >0.05). There were 6 cases of OHSS developed with dual trigger group (Group II) (3 were mild early OHSS, 2 were moderate early and one case was severe late OHSS). In contrast, there was only one case of severe late OHSS seen in Group I. Conclusion: Dual trigger for final oocyte maturation using GnRHa and low-dose hCG is associated with increased the incidence of early OHSS compared to GnRH alone. However, dual trigger appears to be a safe approach with a satisfactory pregnancy outcome. Also, the dual trigger improves the oocyte maturation, the number of yield embryos and the quality of embryos.
Keywords
Dual trigger; gonadotropin-releasing hormone agonist; human chorionic gonadotropin; ovarian hyperstimulation syndrome; luteal phase support; oocyte maturation; quality of embryos
Statistics
Article View: 213
PDF Download: 532