The Potential Role Of Glial Fibrillary Acidic Protein In Evaluation of Organophosphorus- Induced Neurotoxicity: A prospective clinical study | ||||
| Ain Shams Journal of Forensic Medicine and Clinical Toxicology | ||||
| Volume 40, Issue 1, January 2023, Page 101-111 PDF (1.42 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajfm.2023.285299 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Eman Mohammed1; Ali Ali2; Mahmoud Abd El Wahab3; Magdy Mahmoud4 | ||||
| 1Department of Forensic Medicine and Clinical Toxicology, Faculty of medicine Ain Shams University, Cairo, Egypt. | ||||
| 2Poison Control Center Ain Shams Hospitals, Cairo, Egypt. | ||||
| 3Poison Control Center Ain Shams Hospitals, Cairo, Egypt | ||||
| 4Department of Biochemistry, Faculty of Science Ain Shams University, Cairo, Egypt. | ||||
| Abstract | ||||
| Background: Organophosphorus compounds (OPC) poisoning leads to several neurotoxic disorders in humans. Glial Fibrillary Acidic Protein (GFAP) released in response to neuronal cell injury and has been used as a sensitive and specific indicator of several neurotoxic conditions, there is no human studies focused on the diagnostic and prognostic value of GFAP in OPC toxicity. Thus, there is a need for studying its role in OPC poisoning. Objectives: This study aimed to assess the usefulness of GFAP as early predictor of OPC related neurotoxic disorders both in acute poisoning and chronic exposure and to correlate levels of GFAP with severity of acute OPC poisoning. Methods: This is a prospective clinical study that was conducted in Poison Control Center, Ain Shams University Hospitals. The study included 4 groups, control group (23 healthy volunteers), group II acute moderate OPC patients (19 patients), group III acute severe OPC patients (25 patients), and group IV chronic group (41 farmers). All participants were subjected to measurement of GFAP, serum acetylcholine (ACh), serum pseudo cholinesterase (PChE), serum glucose, potassium, serum lactate ,lactate dehydrogenase (LDH), and serum creatine phosphokinase (CPK). Results: Serum GFAP and ACh were significantly high in all patient groups compared to the control group, but no significant difference was found between acute moderate and acute severe groups. Also serum PChE had no significant difference between patients of acute moderate and severe groups. Serum glucose, lactate, LDH and CPK were highly significant in acute severe group when compared to acute moderate group. Conclusion: Glial Fibrillary Acidic Protein, a biomarker of neurotoxicity, can be used in patients with acute and chronic OPC poisoning as early predictor of OP induced brain cell injury. Serum glucose, lactate, LDH and CPK could be used as simple tools in prediction of severity in acute OP poisoning. Received in original form: 14 September 2022 Accepted in final form: 31 January 2023 | ||||
| Keywords | ||||
| organophosphorus compounds; neurotoxicity; Glial Fibrillary Acidic Protein; acetylcholine; predictor | ||||
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