The Ameliorative Effect Of Vitamin C Against Hematological , Biochemical , Oxidative And Immunosuppressive Effect Of Cadmium Chloride In Rats.
Elgharib, I., Abdelhamid, F., E. Elshopakey, G., Fawzy, M., Risha, E. (2023). The Ameliorative Effect Of Vitamin C Against Hematological , Biochemical , Oxidative And Immunosuppressive Effect Of Cadmium Chloride In Rats.. EKB Journal Management System, 54(3), 379-394. doi: 10.21608/ejvs.2023.181316.1417
Inas M. Elgharib; Fatma M. Abdelhamid; Gehad E. Elshopakey; Mohamed Fawzy; Engy F. Risha. "The Ameliorative Effect Of Vitamin C Against Hematological , Biochemical , Oxidative And Immunosuppressive Effect Of Cadmium Chloride In Rats.". EKB Journal Management System, 54, 3, 2023, 379-394. doi: 10.21608/ejvs.2023.181316.1417
Elgharib, I., Abdelhamid, F., E. Elshopakey, G., Fawzy, M., Risha, E. (2023). 'The Ameliorative Effect Of Vitamin C Against Hematological , Biochemical , Oxidative And Immunosuppressive Effect Of Cadmium Chloride In Rats.', EKB Journal Management System, 54(3), pp. 379-394. doi: 10.21608/ejvs.2023.181316.1417
Elgharib, I., Abdelhamid, F., E. Elshopakey, G., Fawzy, M., Risha, E. The Ameliorative Effect Of Vitamin C Against Hematological , Biochemical , Oxidative And Immunosuppressive Effect Of Cadmium Chloride In Rats.. EKB Journal Management System, 2023; 54(3): 379-394. doi: 10.21608/ejvs.2023.181316.1417

The Ameliorative Effect Of Vitamin C Against Hematological , Biochemical , Oxidative And Immunosuppressive Effect Of Cadmium Chloride In Rats.

Egyptian Journal of Veterinary Sciences
Volume 54, Issue 3, May and June 2023, Page 379-394  XML PDF (2.55 MB)
Document Type: Original Article
DOI: 10.21608/ejvs.2023.181316.1417
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Authors
Inas M. Elgharib1; Fatma M. Abdelhamid1; Gehad E. Elshopakey1; Mohamed Fawzy2; Engy F. Risha email 1
1Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
2Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt
Abstract
The current investigation's objective was to ascertain whether vitamin C has a safe-guarding impact in opposition to the harmful effects of cadmium, a heavy metal with a high toxicity and a substantial environmental pollutant. The experimental group consisted of 20 rats divided into 4 groups. The current study was carried out for 30 days. A (control) , B ( cadmium group) 15 mg\kg CdCl2) , (vitamin C group) ( 150 mg\kg vitamin C) , D (CdCl2 15 mg/kg +150 mg/kg b.wt) orally. After 4 weeks blood samples were taken and liver tissues. Findings revealed a substantial drop in RBC count, Hb concentration, and PCV (< P 0.05) and a substantial rise in WBC count (< P 0.05). On another hand, findings also revealed a substantial drop in total protein, albumin and an increase concentration of globulin, total and direct bilirubin. Also increase concentrations of ALP , AST and ALT . In addition to antioxidants GST, GSH, CAT, SOD, rise in MDA of cadmium group in comparison to A group but, when vitamin C combined by cadmium chloride, the results indicated a noticeable improvement in the parameters under study, indicating the therapeutic effect of vitamin C against cadmium chlorides toxicity in rats.
Keywords
Cadmium; Vitamin C; Antioxidant enzymes; Antioxidants parameters; Amelioration potential
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