Plasma Alpha-defensin Levels in Smoker and Non-smoker Male Patients with Type 2 Diabetes Mellitus | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Volume 27, Issue 2, April 2018, Page 113-118 PDF (257.07 K) | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2018.285551 | ||||
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| Authors | ||||
Maggie M. Fawzi  1; Mohamed S. S. Saad2; Hatem M. Salem2
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| 1Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| 2Departments of Internal Medicine (Diabetes and Endocrinology Unit), Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| Abstract | ||||
| Background: Alpha defensins were known to have broad spectrum potent antimicrobial acdtivities. Objectives: To evaluate plasma alpha-defensin 1- 3 levels in smoker and non-smoker male patients with type 2 diabetes mellitus (T2DM). Methodology: The subjects included 50 consecutive current smoker men with T2DM attending the outpatient clinic, Zagazig University Hospitals (Egypt), matched for age and diabetes duration with 50 consecutive non-smoker men with T2DM and 100 healthy men (50 smokers; 50 non-smokers). Associations between α-defensin plasma levels and characteristics of participants were evaluated. Results: Plasma levels of α-defensins were significantly higher in smokers compared with non-smokers in diabetic and non-diabetic subjects (P<0.001 for all comparisons). Ten characteristics of participants that significantly correlated with α-defensins were further analyzed using stepwise multiple linear regression. The final model included four variables explaining 47.0% of the variation in α-defensin level. Presence of diabetes alone accounted for 32.6% of the variation. However, 40.1% of the variation in α-defensins could be explained by including current smoking. Conclusion: Plasma α-defensin 1-3 is elevated in patients with T2DM, and current smoking is combined with a further elevation. Given the known association between α-defensin and serious complications of diabetes, results of the current study should have important clinical implications in the management of patients with T2DM who smoke or think about smoking. | ||||
| Keywords | ||||
| Defensin; Smoking; Type 2 Diabetes | ||||
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