Role of IL17A in Candidemic Patients in ICU at Benha University Hospital | ||||
Egyptian Journal of Medical Microbiology | ||||
Volume 27, Issue 3, July 2018, Page 7-12 PDF (414.55 K) | ||||
Document Type: New and original researches in the field of Microbiology. | ||||
DOI: 10.21608/ejmm.2018.285583 | ||||
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Authors | ||||
Hagar G . El-hawary 1; Wafaa A. El –Mosallamy1; Mahmoud Abd El-sabour Mahmoud1; Sherin M. Emam1; Ihab S. Abd Elazim2 | ||||
1Department of Medical Microbiology and Immunology, Faculty of medicine - Benha University | ||||
2Department of Anesthesia and ICU Faculty of Medicine - Benha University | ||||
Abstract | ||||
Background: IL-17 plays a major protective role against fungal infection in mice and humans. Genetic defects involving IL-17 increase the susceptibility to candidiasis. Objective: This study aimed at assessing the association between serum Interleukin-17A (IL17A) and candida infection in Intensive Care Unit patients with candidemia versus non-candidemic patients. Methodology: 90 individuals were included; 60 ICU patients, divided into 2 groups; group1: 30 patients with Candidemia, group 2: 30 patients with Candida in sputum and/or urine samples and 30 apparently healthy as a control group. All enrolled individuals underwent history taking, physical examination, laboratory assessment for Candida albicans infection and serum IL-17A. Results: IL17A level was significantly high among candidemia group (0.24 0.10 pg/ml) followed by group of candida in urine and sputum (0.08 0.02 pg/ml) (P-value <0.001). Conclusion: There was an association between IL-17A levels and candidemia suggesting its predictive value for a forthcoming invasive candidiasis. | ||||
Keywords | ||||
Interleukin-17; candidemia; Intensive care units | ||||
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