Neoptrin and Complement 3 as Immunomodulatory Clues in Serum & CSF for Septic & Aseptic Meningitis
El-Folly, R., Fathi, M., Abd EL-Kadder, S., Fathi, L., Ezz Elarab, M., El Fouly, N. (2018). Neoptrin and Complement 3 as Immunomodulatory Clues in Serum & CSF for Septic & Aseptic Meningitis. EKB Journal Management System, 27(3), 37-44. doi: 10.21608/ejmm.2018.285588
Runia El-Folly; Marwa S. Fathi; Soheir Abd EL-Kadder; Lamia F. Fathi; Mohamed Ezz Elarab; Nevien F. El Fouly. "Neoptrin and Complement 3 as Immunomodulatory Clues in Serum & CSF for Septic & Aseptic Meningitis". EKB Journal Management System, 27, 3, 2018, 37-44. doi: 10.21608/ejmm.2018.285588
El-Folly, R., Fathi, M., Abd EL-Kadder, S., Fathi, L., Ezz Elarab, M., El Fouly, N. (2018). 'Neoptrin and Complement 3 as Immunomodulatory Clues in Serum & CSF for Septic & Aseptic Meningitis', EKB Journal Management System, 27(3), pp. 37-44. doi: 10.21608/ejmm.2018.285588
El-Folly, R., Fathi, M., Abd EL-Kadder, S., Fathi, L., Ezz Elarab, M., El Fouly, N. Neoptrin and Complement 3 as Immunomodulatory Clues in Serum & CSF for Septic & Aseptic Meningitis. EKB Journal Management System, 2018; 27(3): 37-44. doi: 10.21608/ejmm.2018.285588

Neoptrin and Complement 3 as Immunomodulatory Clues in Serum & CSF for Septic & Aseptic Meningitis

Egyptian Journal of Medical Microbiology
Volume 27, Issue 3, July 2018, Page 37-44  XML PDF (283.48 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2018.285588
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Authors
Runia El-Folly1; Marwa S. Fathi email 2; Soheir Abd EL-Kadder* 1; Lamia F. Fathi2; Mohamed Ezz Elarab3; Nevien F. El Fouly4
1Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Medical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Hepatology and Gastroenterology, Internal Medicine Department, Ahmed Maher Educational Hospital, Cairo, Egypt
4Health Radiation Research Department, National Center for Radiation Research and Technology, Cairo, Egypt
Abstract
Background: Distinguishing septic and aseptic meningitis in the emergency department could help limit unnecessary antibiotic use and hospital admissions. Objectives: To assess the potential diagnostic role of serum and cerebrospinal fluid (CSF) neopterin and complement 3 (C3) levels as a rapid diagnostic method for differential diagnosis of septic and aseptic meningitis. Methodology: Forty patients with proven acute meningitis, were categorized into 2 groups, Group I: 20 patients with septic (bacterial) meningitis as confirmed by CSF analysis and positive Gram stain and/or conventional bacterial culture; Group II: 20 patients with proved aseptic meningitis (viral and fungal) as confirmed by CSF analysis with negative culture for bacteria. Serum/CSF neopterin was assayed by Enzyme Linked Immunosorbent Assay (ELISA) while C3 level in serum was assayed by single radial immune diffusion. Results. The simultaneous elevation in serum and CSF neopterin shows high significance in the diagnosis of septic meningitis cases (P < 0.001). Conclusion. The combined elevated serum and CSF neopterin has a remarkable application in the diagnosis of bacterial meningitis, and can thus help differentiate bacterial from aseptic meningitis
Keywords
Cerebrospinal fluid; Complement 3; Patients; Brain; Septic versus Aseptic Meningitis
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