Study of Plasminogen activator inhibitor-1 (PAI-1) in hospitalized COVID-19 patients | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 100, Volume 90, Issue 2, January 2023, Page 2651-2655 PDF (364.87 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2023.286415 | ||||
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Authors | ||||
Aya Mohamed Boshta ; Mohamed Hossny Fouda; Mohamed Sayed Hantera; Enass Arafa El-Zamrany | ||||
Abstract | ||||
Background: There is an evidence that COVID-19 individuals have impaired fibrinolysis, which may increase their thrombotic risk further. Hepatocytes and endothelial cells are responsible for the synthesis of plasminogen activator inhibitor-1 (PAI-1). It is the primary inhibitor of tissue-type plasminogen activator (t-PA) and has a crucial role in fibrinolysis control. The purpose of our research was to measure the plasma levels of PAI-1 in Patients with COVID-19 who were hospitalized. Methods:In the current research, 40 Patients with COVID-19 and 40 healthy participants served as controls. Enzyme-linked immune-sorbent assay (ELISA) was used to measure plasma PAI-1 levels. Results: There was a considerable elevation in WBCs count and segmented WBCs in cases compared to control with significant decrease in lymphocytes in cases compared to control group. PAI-1, CRP, LDH, Ferritin and D-Dimer were remarkably raised in patients compared to control group.There was positive significant correlation between PAI-1 levels and urea, creatinine, AST, LDH, ferritin, D-Dimer and CRP. PAI-1 showed 93% sensitivity and 87% specificity at cut off 5.5 ng/ml in discriminating patients from control group < strong>. Conclusions: Plasma concentrations of PAI-1, a measure of fibrinolytic homeostasis, were higher in ICU patients with COVID-19. This research also showed that PAI-1 may be added to the list of biomarkers used to define Patients with COVID-19. | ||||
Keywords | ||||
COVID-19; Biomarkers; PAI-1; Fibrinolytic; Homeostasis | ||||
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