Role of Hormonal alteration and FSHR genes polymorphism in development of primary amenorrhea of Upper Egyptians teenagers.
Anwar, S., El ktatny, H., Hashem, K., Ahmed, A. (2023). Role of Hormonal alteration and FSHR genes polymorphism in development of primary amenorrhea of Upper Egyptians teenagers.. EKB Journal Management System, 66(11), 435-441. doi: 10.21608/ejchem.2023.168822.7089
Sara Anwar; Hossam El ktatny; Khalid Hashem; Amr el-sayed Ahmed. "Role of Hormonal alteration and FSHR genes polymorphism in development of primary amenorrhea of Upper Egyptians teenagers.". EKB Journal Management System, 66, 11, 2023, 435-441. doi: 10.21608/ejchem.2023.168822.7089
Anwar, S., El ktatny, H., Hashem, K., Ahmed, A. (2023). 'Role of Hormonal alteration and FSHR genes polymorphism in development of primary amenorrhea of Upper Egyptians teenagers.', EKB Journal Management System, 66(11), pp. 435-441. doi: 10.21608/ejchem.2023.168822.7089
Anwar, S., El ktatny, H., Hashem, K., Ahmed, A. Role of Hormonal alteration and FSHR genes polymorphism in development of primary amenorrhea of Upper Egyptians teenagers.. EKB Journal Management System, 2023; 66(11): 435-441. doi: 10.21608/ejchem.2023.168822.7089

Role of Hormonal alteration and FSHR genes polymorphism in development of primary amenorrhea of Upper Egyptians teenagers.

Egyptian Journal of Chemistry
Volume 66, Issue 11, November 2023, Page 435-441  XML PDF (311.89 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.168822.7089
View on SCiNiTO View on SCiNiTO
Authors
Sara Anwar1; Hossam El ktatny2; Khalid Hashem email orcid 3; Amr el-sayed Ahmedorcid 4
1Department of Biotechnology and life sciences, Faculty of postgraduate studies for advanced sciences, Beni-Suef University
2bDepartment of Gynecology & Obstetrics, Faculty of Medicine, Al-Azhar University, Assuit Branch
3veterinary college
4biotechnology department, faculty of post graduate for advanced sciences, beni-suef univesity.
Abstract
Amenorrhea is the absence or abnormal cessation of menses. Primary and secondary amenorrhea describes the occurrence of amenorrhea before and after menarche, respectively. We aimed to investigate the hormonal changes and FSHR gene polymorphism in teenager females with primary amenorrhea. For this purpose, 100 adult women (age 25 ± 10 years) were examined for the appearance of the signs of puberty and menstruation for detecting the cases of primary amenorrhea. The women were divided into two main groups, normal women and amenorrhea. Gonadotrophic hormones, overian hormones, anti-mullerian hormone (AMH), oxidative/ antioxidant redox and Follicular stimulating hormone receptor (FSHR) were tested in all groups. Our results showed that women with amenorrhea suffered from high FSH, LH and prolactin compared to normal women. In addition, a significant reduction of ovarian hormones was detected in women with amenorrhea compared to normal women with a concurrent alteration of antioxidant/oxidative redox. A significant reduction of antimullerian hormone (AMH) and FSH receptors (FSHR) also recorded in amenorheastic women. We can concluded that amenorrhea is associated with sever hormonal dys-regulation, AMH could be used as a significant biomarker in diagnosis of amenorrhea and FSHR plays a pivotal role in the development of amenorrhea.
Keywords
Amenorrhea; FSH; FSHR and infertility
Statistics
Article View: 181
PDF Download: 54