Ultrastructural study of the hepatoprotective effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced toxicity in the female albino rats. | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 69, Issue 1, 2023, Page 1-12 PDF (539.6 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.2023.193695.1023 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Omnia Shalaby  ; Elbargeesy G. A.; Yasmine H. Ahmed; Aya M. Mekkawy
| ||||
| Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo university | ||||
| Abstract | ||||
| Background: Silver nanoparticles (Ag-NPs) are increasingly used in industrial and biological applications. There are growing worries regarding their toxicity to both humans and animals. Selenium-loaded chitosan nanoparticles (CS-SeNPs) have strong antioxidant properties via scavenging free radicals. Objective: The aim of this study is to assess the protective effect of CS-SeNPs against Ag-NPs' damaging effects on the hepatic tissue of adult female rats. Methods: Forty female albino rats were separated into four groups: group I (control) was given distilled water (0.5 ml/kg), group II was administered Ag-NPs (100 mg/kg), group III was co-exposed with Ag-NPs (100 mg/kg) and CS-SeNPs (0.5 mg/kg) and group IV received only CS-SeNPs (0.5 mg/kg) daily by oral gavage. After 60 days, rats were euthanized, then hepatic tissues were collected and fixed in 5% glutaraldehyde for transmission electron microscopy. Results: Exposure to Ag-NPs induced severe degeneration of the hepatocytes, in the form of complete lysis and disappearance of the cytoplasmic organelles. While supplementation with CS-SeNPs exhibited a partial disappearance of most degenerative changes induced by Ag-NPs. In conclusion, Ag-NPs induce some destructive effects on the hepatic tissue and CS-SeNPs can ameliorate most of these harmful effects. | ||||
| Keywords | ||||
| Keywords: Silver nanoparticles; Selenium-loaded chitosan nanoparticles; Hepatotoxicity; Ultrastructure | ||||
|
Statistics Article View: 106 PDF Download: 37 |
||||
