Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 1, January 2023, Page 555-561 PDF (684.77 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.132916.5870 | ||||
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| Authors | ||||
Zainab Faiyq Saeed1; Mohanad Yakdhan Saleh   2; ghufran thanoon sadeek 3
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| 1Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul | ||||
| 2Department of Chemistry, College of Education for pure science, University of Mosul | ||||
| 3department of chemistry, college of Education for pure science | ||||
| Abstract | ||||
| In this paper, a new series of substituted 1, 2,4-triazines was prepared by reacting 4-amino sulfanilic acid with substituted benzaldehyde to form the corresponding Schiff base compounds (1-5), and then reacting two moles of O-methoxy benzaldehyde with hydrazine to form a compound (6) and these compounds reacted with Schiff base (1-5) by applying the Diels-alder reaction in the presence of benzene as a solvent and refluxed it to cyclized into substituted of 1,2,4- triazines derivatives (7-11). Depending on the physical and spectroscopic properties of the prepared compounds that were identified, infrared spectroscopy and nuclear magnetic resonance were used. An evaluation of the biological activity of the prepared compounds was conducted and it gave anti-bacterial results, such as gram-positive and gram-negative when compared with known antibiotics. | ||||
| Keywords | ||||
| 1; 2; 4-triazine; Sulfanilic Acid | ||||
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