Long-term Follow-up of Chronic Hepatitis C Patients Treated by Direct- Acting Antivirals
Tawheed, A., El-Kassas, M., El-Fouly, A., Esmat, G. (2023). Long-term Follow-up of Chronic Hepatitis C Patients Treated by Direct- Acting Antivirals. EKB Journal Management System, 90(2), 2767-2774. doi: 10.21608/ejhm.2023.287321
Ahmed Tawheed; Mohamed El-Kassas; Amr El-Fouly; Gamal Esmat. "Long-term Follow-up of Chronic Hepatitis C Patients Treated by Direct- Acting Antivirals". EKB Journal Management System, 90, 2, 2023, 2767-2774. doi: 10.21608/ejhm.2023.287321
Tawheed, A., El-Kassas, M., El-Fouly, A., Esmat, G. (2023). 'Long-term Follow-up of Chronic Hepatitis C Patients Treated by Direct- Acting Antivirals', EKB Journal Management System, 90(2), pp. 2767-2774. doi: 10.21608/ejhm.2023.287321
Tawheed, A., El-Kassas, M., El-Fouly, A., Esmat, G. Long-term Follow-up of Chronic Hepatitis C Patients Treated by Direct- Acting Antivirals. EKB Journal Management System, 2023; 90(2): 2767-2774. doi: 10.21608/ejhm.2023.287321

Long-term Follow-up of Chronic Hepatitis C Patients Treated by Direct- Acting Antivirals

The Egyptian Journal of Hospital Medicine
Article 117, Volume 90, Issue 2, January 2023, Page 2767-2774  XML PDF (269.24 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.287321
View on SCiNiTO View on SCiNiTO
Authors
Ahmed Tawheedorcid ; Mohamed El-Kassasorcid ; Amr El-Fouly; Gamal Esmat
Abstract
Background: Hepatitis C virus HCV infection is one of the main causes of chronic liver disease worldwide, Egypt has the highest national-level HCV prevalence in the world, and direct Acting Antivirals are widely used to treat HCV infection in Egypt. Aim: To perform a long-term follow-up of patients with chronic hepatitis C who received IFN free regimen of direct-acting antivirals (DAAs). The follow-up aimed to study the incidence of hepatocellular carcinoma, viral recurrence in this cohort of patients and improvement of liver biochemicals or liver decompensation.
Methodology: We recruited 1041 Egyptian HCV patients, who finished treatment more than 1 year before recruitment and then we assessed the improvement of the biochemical profile and the liver condition, incidence of occurrence or recurrence hepatocellular carcinoma after treatment.
Results: The follow-up values of ALT, AST, INR, Bilirubin, Platelets and fibrosis-4 (Fib-4) showed a statistically significant improvement more than 1 year after treatment, while the improvement in albumin and AFP was noted without statistical significancy. By comparing the different groups of the study, patients with advanced liver disease showed a greater improvement in those parameters. However, they carried an increased risk of developing hepatocellular carcinoma.
Conclusion: Achieving SVR using DAAs can improve liver functions tests, AFP, platelet count and FIB-4 value and persons with severe liver disease should be advised to undergo HCC surveillance after achieving sustained virological response (SVR).
 
Keywords
HCV; DAAs; Long-term; Hepatitis C virus
Statistics
Article View: 127
PDF Download: 249