Impact of Cytomegalovirus (CMV) Infection on Renal Transplantation and Graft Rejection.
Ahmed, H., Fadel, F., Ghobrial, E., Ali, A. (2022). Impact of Cytomegalovirus (CMV) Infection on Renal Transplantation and Graft Rejection.. EKB Journal Management System, 17(2), 31-40. doi: 10.21608/geget.2022.287744
Hanan Abdel Aziz Ahmed; Fatina I Fadel; Emad E Ghobrial; Aliaa Ali. "Impact of Cytomegalovirus (CMV) Infection on Renal Transplantation and Graft Rejection.". EKB Journal Management System, 17, 2, 2022, 31-40. doi: 10.21608/geget.2022.287744
Ahmed, H., Fadel, F., Ghobrial, E., Ali, A. (2022). 'Impact of Cytomegalovirus (CMV) Infection on Renal Transplantation and Graft Rejection.', EKB Journal Management System, 17(2), pp. 31-40. doi: 10.21608/geget.2022.287744
Ahmed, H., Fadel, F., Ghobrial, E., Ali, A. Impact of Cytomegalovirus (CMV) Infection on Renal Transplantation and Graft Rejection.. EKB Journal Management System, 2022; 17(2): 31-40. doi: 10.21608/geget.2022.287744

Impact of Cytomegalovirus (CMV) Infection on Renal Transplantation and Graft Rejection.

GEGET
Volume 17, Issue 2, December 2022, Page 31-40  XML PDF (232.12 K)
Document Type: Original Article
DOI: 10.21608/geget.2022.287744
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Authors
Hanan Abdel Aziz Ahmed email 1; Fatina I Fadel1; Emad E Ghobrial1; Aliaa Ali2
1Department of Pediatrics, Kasr Al Ainy, School of Medicine, Cairo University, Cairo, Egypt.
2Department of Pediatrics, Ministry of Health, Egypt
Abstract
Introduction: cytomegalovirus (CMV) infection is a common problem among kidney transplant patients. It can affect patient morbidity and graft survival. It is also associated with acute and chronic graft rejection.
Aim of the study: The aim of this work is to show the prevalence and natural course post-kidney transplantation of CMV infection and the effect of CMV on patient morbidity and mortality.
Methods: This cohort study was performed at Children Hospital, Cairo University during the period from May 2016 to January 2018, including thirty pediatric renal transplanted patients diagnosed as end-stage renal disease (ESRD) and had kidney transplantation. Patients were divided into two groups; patients' group with CMV infection and control group without CMV infection. CMV infection was diagnosed by quantitative polymerase chain reaction.
Results: Patients were divided according to PCR as CMV positive group [8 patients (26.7%)] and negative group [22 patients (73.3%)]. There was a statistically significant difference between 2 studied groups as regard chest infection (p= 0.019), height (p= 0.003) and hemodialysis duration (p= 0.022) in the CMV positive patients. Urinary tract infection was the major co-morbidity in the 2 groups (59.1% in the negative patients and 75% in the positive patients), followed by hypertension (18.2% in the negative patients and 37.5% in the positive group). No statistically significant difference in the rejection episodes in both groups.
Conclusion: CMV disease can increase the risk of infections like chest infection and UTI and a risk factor for cardiovascular diseases as hypertension
Keywords
CMV; renal transplantation; children
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