Potent Therapeutic Effects of Polysaccharides Isolated From Some Edible Plant Wastes: Characterization and Bioactivities
El Sawi, S., Aly, H., Sleem, A., El-Feky, A., eL Batanony, M. (2022). Potent Therapeutic Effects of Polysaccharides Isolated From Some Edible Plant Wastes: Characterization and Bioactivities. EKB Journal Management System, 65(131), 1401-1416. doi: 10.21608/ejchem.2022.153901.6660
Salma Ahmed El Sawi; Hanan Farouk Aly; Amany Sleem; Amal El-Feky; Marwa eL Batanony. "Potent Therapeutic Effects of Polysaccharides Isolated From Some Edible Plant Wastes: Characterization and Bioactivities". EKB Journal Management System, 65, 131, 2022, 1401-1416. doi: 10.21608/ejchem.2022.153901.6660
El Sawi, S., Aly, H., Sleem, A., El-Feky, A., eL Batanony, M. (2022). 'Potent Therapeutic Effects of Polysaccharides Isolated From Some Edible Plant Wastes: Characterization and Bioactivities', EKB Journal Management System, 65(131), pp. 1401-1416. doi: 10.21608/ejchem.2022.153901.6660
El Sawi, S., Aly, H., Sleem, A., El-Feky, A., eL Batanony, M. Potent Therapeutic Effects of Polysaccharides Isolated From Some Edible Plant Wastes: Characterization and Bioactivities. EKB Journal Management System, 2022; 65(131): 1401-1416. doi: 10.21608/ejchem.2022.153901.6660

Potent Therapeutic Effects of Polysaccharides Isolated From Some Edible Plant Wastes: Characterization and Bioactivities

Egyptian Journal of Chemistry
Volume 65, Issue 131, December 2022, Page 1401-1416  XML PDF (462.08 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.153901.6660
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Authors
Salma Ahmed El Sawi1; Hanan Farouk Alyorcid 2; Amany Sleem3; Amal El-Feky email orcid 4; Marwa eL Batanonyorcid 5
1Department of Pharmacognosy, National Research Centre
2Deprtment of Therapeutic Chemistry , National Research Centre (NRC),El Behouth St. , P.O.12622. Dokki, Giza, Egypt.
3Pharmacology Department, National Research Centre, Dokki, Giza, Egypt
4Pharmacognosy Department, Pharmaceutical and Drug Industries Research Division, National Research Centre.
5prof. National Research Centre
Abstract
Polysaccharides have various effects and exhibit several bioactivities that possess an enormous influence on healthcare due to their therapeutic beneficial and comparatively low toxicity. The study is focusing in investigation of the chemical structure of the isolated polysaccharides from wastes of Punica granatum, Musa acuminate, and Brassica oleracea, beside to validation of the analgesic, anti-inflammatory, antipyretic and antiulcer activities. Moreover, the polysaccharide yields were determined, characterization of the hydrolyzates was performed using UV-visible, FT-IR, 1HNMR and GLC analyses. In addition, significant biological activities were obviously presented by all the isolated polysaccharides. The highest analgesic and anti-inflammatory activities exhibited by polysaccharides of B. oleracea outer leaves (62.98 and 81.69 %), followed by that of P. granatum peels (53.31 and 78.17%), and that of M. acuminate peels (50.50 and 76.05%), while the antipyretic activity was showed nearly the same results for both M. acuminate and B. oleracea polysaccharides (6.59 and 6.35%), then that of P. granatum peels (5.30%). On the other, the antiulcer activities of polysaccharides of different wastes showed corrective action of inflammatory markers including tumor necrosis factor -α (TNF-α), interleukin -6, 8 (IL-6 &8), myeloperoxidase (MPO) as well as lowering oxidative stress, improved lesion count which lead to ameliorations in histopathological picture of stomach. In conclusion, the polysaccharide isolated from Musa acuminate showed the most potent therapeutic effect in the majority of the biomarkers under investigation.
Keywords
Punica granatum; Musa acuminate; Brassica oleracea; polysaccharides; antiulcer; antipyretic
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