Correlation between Molecular Changes and Inflammatory Cascade in Deep Carious Lesions with Dental Pulp Exposure Using Superoxide Dismutase | ||||
| Mansoura Journal of Dentistry | ||||
| Volume 10, Issue 1, March 2023, Page 53-57 PDF (501.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjd.2023.288117 | ||||
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| Abstract | ||||
| Objective: To use Superoxide dismutase (SOD) as a diagnostic biomarker to correlate molecular changes in the inflammatory cascade in deep carious lesions with dental pulp exposure.Materials and Methods: A total of 40 cases with deep carious lesions with expected pulp exposure and signs of pulp vitality without signs of periapical inflammation were selected from the outpatient clinic, Faculty of Dentistry, Mansoura University. Another 6 control cases were selected from the orthodontics department clinic. Results: Our results show that there is a statistically significantly lower mean percent inhibition among cases than in the control group 63.31±24.61versus 94.52±2.97 (p=0.004). However, there appears to be no statistically significant difference between the different treatment modalities as regard mean percent inhibition with the highest mean percent of inhibition being among direct pulp capping cases 75.35±13.51 followed by partial pulpotomy 67.18±24.35, 60.66±28.15 for complete pulpotomy and 58.81±25.22 for RCT (P=0.708).Conclusions: Vital pulp therapy is an ultra-conservative treatment that can be applied with the proper tools and magnification with a high success rate based on clinical signs and symptoms. However, in terms of treatment decisions, a molecular diagnosis does not appear to be superior to direct tissue visualization. | ||||
| Keywords | ||||
| Biomarkers; Inflammation; Deep carious lesion; Dental pulp exposure | ||||
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