Assessment of Liver Fibrosis Using Real Time Elastography and FIB 4 Score in Comparison to Liver Biopsy in Chronic HCV Egyptian Patients
Rashed, H., Eltebi, D., Eissa, A., El Kassas, M. (2019). Assessment of Liver Fibrosis Using Real Time Elastography and FIB 4 Score in Comparison to Liver Biopsy in Chronic HCV Egyptian Patients. EKB Journal Management System, 74(8), 1836-1843. doi: 10.21608/ejhm.2019.28860
Hassan Abd El Hafiez Rashed; Diaa Mohamed Eltebi; Ahmed Hany Eissa; Mohamed Mahmoud El Kassas. "Assessment of Liver Fibrosis Using Real Time Elastography and FIB 4 Score in Comparison to Liver Biopsy in Chronic HCV Egyptian Patients". EKB Journal Management System, 74, 8, 2019, 1836-1843. doi: 10.21608/ejhm.2019.28860
Rashed, H., Eltebi, D., Eissa, A., El Kassas, M. (2019). 'Assessment of Liver Fibrosis Using Real Time Elastography and FIB 4 Score in Comparison to Liver Biopsy in Chronic HCV Egyptian Patients', EKB Journal Management System, 74(8), pp. 1836-1843. doi: 10.21608/ejhm.2019.28860
Rashed, H., Eltebi, D., Eissa, A., El Kassas, M. Assessment of Liver Fibrosis Using Real Time Elastography and FIB 4 Score in Comparison to Liver Biopsy in Chronic HCV Egyptian Patients. EKB Journal Management System, 2019; 74(8): 1836-1843. doi: 10.21608/ejhm.2019.28860

Assessment of Liver Fibrosis Using Real Time Elastography and FIB 4 Score in Comparison to Liver Biopsy in Chronic HCV Egyptian Patients

The Egyptian Journal of Hospital Medicine
Article 21, Volume 74, Issue 8, January 2019, Page 1836-1843  XML PDF (547.92 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.28860
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Authors
Hassan Abd El Hafiez Rashed1; Diaa Mohamed Eltebi1; Ahmed Hany Eissa email 1; Mohamed Mahmoud El Kassas2
1Department of tropical medicine, Faculty of Medicine - Al-Azhar University
2National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt
Abstract
Background: HCV is one of the etiologies causing liver fibrosis through direct deposition of extracellular matrix in the liver as a response to wound healing to compensate for the injury Aim of this study: Assessment of liver fibrosis using sonography-based real time elastography (RTE) and FIB 4 score in comparison to liver biopsy for assessment of the stage of liver fibrosis in chronic Egyptian HCV patients. Patients and methods:116 patients with HCV were enrolled in the study from 2014-2015 in the National Hepatology and Tropical Medicine Research Institute Outpatient Clinics, Cairo, Egypt. Results: The mean RTELFI of the studied group was 2.68 ± 0.74. The correlation between different fibrosis stages, FIB-4 and RTELFI showed significant relations between the degree of hepatic fibrosis and FIB-4 with p = 0.001 & RTELFI with p < 0.001. Positive correlation was detected between fibrosis stage, FIB-4 and RTELFI. At a cutoff value of 3.26 for RTELFI, the test had a sensitivity of 72% and a specificity of 90% in detecting advanced fibrosis with AUC = 0.791 (95% confidence interval 0.649-0.933). At a cutoff value of 2.26 for FIB-4 index, the test had a sensitivity of 50% and a specificity of 87% in detecting advanced fibrosis with AUC = 0.797 (95% confidence interval 0.683-0.911). Conclusion: RTE has excellent accuracy for F4 and F ≥ 3 and is superior to FIB-4.
Keywords
RTE; FIB4; HCV
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