Fecal carriage rates Of extended-spectrum Β-lactamase-producing Escherichia coli of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.
Mustapha, A., Chidiebere, O., Bata, M., Ali, Z., Victor, F., Yakubu, M., Tanko, N., David, A. (2023). Fecal carriage rates Of extended-spectrum Β-lactamase-producing Escherichia coli of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.. EKB Journal Management System, 4(4), 1173-1177. doi: 10.21608/mid.2023.182614.1432
Adam Mustapha; Obi Chidiebere; Mari Bata; Zenoh Danjuma Ali; Fasogbon Ilemobayo Victor; Micheal Nosano Yakubu; Nuhu Tanko; Alegbe Sunday David. "Fecal carriage rates Of extended-spectrum Β-lactamase-producing Escherichia coli of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.". EKB Journal Management System, 4, 4, 2023, 1173-1177. doi: 10.21608/mid.2023.182614.1432
Mustapha, A., Chidiebere, O., Bata, M., Ali, Z., Victor, F., Yakubu, M., Tanko, N., David, A. (2023). 'Fecal carriage rates Of extended-spectrum Β-lactamase-producing Escherichia coli of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.', EKB Journal Management System, 4(4), pp. 1173-1177. doi: 10.21608/mid.2023.182614.1432
Mustapha, A., Chidiebere, O., Bata, M., Ali, Z., Victor, F., Yakubu, M., Tanko, N., David, A. Fecal carriage rates Of extended-spectrum Β-lactamase-producing Escherichia coli of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.. EKB Journal Management System, 2023; 4(4): 1173-1177. doi: 10.21608/mid.2023.182614.1432

Fecal carriage rates Of extended-spectrum Β-lactamase-producing Escherichia coli of inpatients and outpatients attending Yobe State Teaching Hospital, Damaturu, Nigeria.

Microbes and Infectious Diseases
Article 14, Volume 4, Issue 4, November 2023, Page 1173-1177  XML PDF (687.3 K)
Document Type: Original Article
DOI: 10.21608/mid.2023.182614.1432
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Authors
Adam Mustapha email orcid 1; Obi Chidiebereorcid 2; Mari Bataorcid 2; Zenoh Danjuma Aliorcid 3; Fasogbon Ilemobayo Victororcid 4; Micheal Nosano Yakubuorcid 5; Nuhu Tankoorcid 6; Alegbe Sunday Davidorcid 7
1Department of Microbiology, Faculty of Science, University of Maiduguri, Nigeria.
2Department of Microbiology, Faculty of Science, Federal University Birnin Kebbi, Kebbi State, Nigeria
3Department of Medical Laboratory Science, Faculty of Health Sciences, Taraba State University Jalingo
4Department of Biochemistry, Kampala International University Western Campus, Ishaka, Uganda
5Department of Microbiology, Faculty of Science, Federal University Wukari, Taraba State
6Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University Sokoto
7Department of Microbiology, Faculty of Life Science, Ahmadu Bello University Zaria.
Abstract
Background: Extended-spectrum β-lactamases-producing Escherichia coli has been on rise and its infection is becoming difficult to treat. These resistant bacteria can colonize human gastrointestinal tract and can easily be spread in population. The aim of this study was to assess the fecal carriage rates of extended spectrum beta lactamase-producing E. coli (ESBL) among hospitalized and out-patients.  Methods: A total of 200 volunteers participated in the study. A stool sample was collected from each participant and subjected to standard microbiological methods for the isolation of E. coli. Furthermore, the isolates were subjected to phenotypic detection of ESBL using double-disk synergy test. The confirmatory test was performed with CAZ (30μg), CTX (30μg) and CRO (30μg) around Augmentin disc (AMC 30μg) and clear zone of inhibitions towards the AMC (30μg) considered as positive results for production of ESBL. Basic demographic information were recorded. Results: From the 200 fecal samples collected, all tested positive for E. coli. 108 females participated which represents (54%) while 92 males participated which represents (46%) and their age group ranges between 21years to 40years (n =94/200; 47%). Among the participants, 113/200 (56. 5%) were out-patients while 87/200 representing 43.5% were hospitalized patients. In this study, 116/200 (58%) of the 200 volunteers were found to harbored E. coli producing ESBL. In this study, age, gender, and hospitalization status play role in fecal carriage rates of ESBL-producing E. coli.  Conclusion: The results of this study reveal high fecal colonization of ESBL-producing E. coli. Therefore, there is need for prudent use of antibiotics among hospitalized and out-patientsز
Keywords
Extended-spectrum beta lactamase; E. coli; antibiotic resistance; fecal carriage; Nigeria
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