Nanocomposite for Enhancement the Biological Activity of Cu(II)-complex from New Cefotaxime Derivative
Abd El-Zahir, M., Soliman, M., ELKady, H., El-Sakka, S., Orabi, A. (2023). Nanocomposite for Enhancement the Biological Activity of Cu(II)-complex from New Cefotaxime Derivative. EKB Journal Management System, 5(1), -. doi: 10.21608/fsrt.2023.195650.1086
Mustafa Abd El-Zahir; Mohamed H. A. Soliman; Hamdy A. ELKady; Sahar S. A. El-Sakka; Adel S. Orabi. "Nanocomposite for Enhancement the Biological Activity of Cu(II)-complex from New Cefotaxime Derivative". EKB Journal Management System, 5, 1, 2023, -. doi: 10.21608/fsrt.2023.195650.1086
Abd El-Zahir, M., Soliman, M., ELKady, H., El-Sakka, S., Orabi, A. (2023). 'Nanocomposite for Enhancement the Biological Activity of Cu(II)-complex from New Cefotaxime Derivative', EKB Journal Management System, 5(1), pp. -. doi: 10.21608/fsrt.2023.195650.1086
Abd El-Zahir, M., Soliman, M., ELKady, H., El-Sakka, S., Orabi, A. Nanocomposite for Enhancement the Biological Activity of Cu(II)-complex from New Cefotaxime Derivative. EKB Journal Management System, 2023; 5(1): -. doi: 10.21608/fsrt.2023.195650.1086

Nanocomposite for Enhancement the Biological Activity of Cu(II)-complex from New Cefotaxime Derivative

Frontiers in Scientific Research and Technology
Volume 5, Issue 1, March 2023  XML PDF (924.8 K)
Document Type: Original Article
DOI: 10.21608/fsrt.2023.195650.1086
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Authors
Mustafa Abd El-Zahir email 1; Mohamed H. A. Soliman2; Hamdy A. ELKady1; Sahar S. A. El-Sakka3; Adel S. Orabi4
1Department of Science and Mathematics Engineering, Faculty of Petroleum and Mining Engineering, Suez University, Suez, Egypt
2Chemistry department, Faculty of Science, Suez University, Suez, Egypt
3Chemistry department, Faculty of Science, Suez University, Suez,Egypt
4Chemistry department, Faculty of Science, Suez Canal University, Ismailia, Egypt
Abstract
A novel cefotaxime derivative, Schiff base ligand, is used to create copper complex. Molar conductivity, elemental study, Infrared, uv-vis spectra, magnetic moment, and thermal behavior are used to describe the complex. The compound molar ratio is discovered to be one metal to one ligand. The infrared bands show that the Schiff base binds copper ion as tridentate via carboxylate, acetylacetone carbonyl and imine group.The magnetic moment, uv-vis transitions, and ESR spectrum, on the other hand, show that the CuII-complex structure is octahedral. Thermal analysis also reveals the presence of water and methyl alcohol in the compound. Moreover, Sol-gel process is utilized for silica nanoparticles preparation. While, the complex is loaded on silica nanoparticles after surface modification. Whereas, the CuII-complex and nano-complex are tested for Gram (+) (B. subtilis and S. aureus) and Gram (-) (E. coli and P. aeruginosa) microbes. The biological results exposed that the synthesized complex has high potential to overcome the resistance of microbes.
Keywords
nanotechnology; spectroscopy; TGA; antimicrobial
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